期刊
ORAL ONCOLOGY
卷 121, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2021.105451
关键词
Oral cavity squamous cell carcinoma (OCSCC); Oral cavity cancer (OCC); Risk factor; Genetic alterations; Signaling; Diagnostic; Treatment
Oral cavity squamous cell carcinoma is the most common malignancy in the oral cavity, with risk factors such as tobacco and alcohol consumption. Late diagnosis leads to decreased survival rates. Understanding the genetic alterations and molecular mechanisms involved is crucial for developing targeted treatments for oral cavity cancer.
Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral cavity. The substantial risk factors for OCSCC are the consumption of tobacco products, alcohol, betel quid, areca nut, and genetic alteration. However, technological advancements have occurred in treatment, but the survival decreases with late diagnosis; therefore, new methods are continuously being investigated for treatment. In addition, the rate of secondary tumor formation is 3-7% yearly, which is incomparable to other malignancies and can lead to the disease reoccurrence. Oral cavity cancer (OCC) arises from genetic alterations, and a complete understanding of the molecular mechanism involved in OCC is essential to develop targeted treatments. This review aims to update the researcher on oral cavity cancer, risk factors, genetic alterations, molecular mechanism, classification, diagnostic approaches, and treatment.
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