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Genetic and epigenetic studies in non-syndromic oral clefts

期刊

ORAL DISEASES
卷 28, 期 5, 页码 1339-1350

出版社

WILEY
DOI: 10.1111/odi.14146

关键词

epigenetics; genetics; Non-syndromic clefts

资金

  1. National Institute of Dental and Craniofacial Research [DE028300]

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The etiology of non-syndromic oral clefts is complex and involves genetics, genomics, epigenetics, and stochastic factors. Various approaches have been used to understand the etiology, including linkage analysis, candidate gene association studies, genome-wide association studies, whole-genome sequencing, copy number variations, and epigenetics. This review shares the methods, genes, and loci reported in some studies.
The etiology of non-syndromic oral clefts (NSOFC) is complex with genetics, genomics, epigenetics, and stochastics factors playing a role. Several approaches have been applied to understand the etiology of non-syndromic oral clefts. These include linkage, candidate gene association studies, genome-wide association studies, whole-genome sequencing, copy number variations, and epigenetics. In this review, we shared these approaches, genes, and loci reported in some studies.

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