4.7 Article

Evaluation of Targeted Next-Generation Sequencing for the Management of Patients Diagnosed with a Cancer of Unknown Primary

期刊

ONCOLOGIST
卷 27, 期 1, 页码 E9-E17

出版社

OXFORD UNIV PRESS
DOI: 10.1093/oncolo/oyab014

关键词

next generation sequencing; cancer genetics; cancer of unknown primary; pharmacogenetics; precision medicine

类别

资金

  1. Moffitt Cancer Center [NIH P30-CA076292]
  2. ASHP Foundation

向作者/读者索取更多资源

This study retrospectively evaluated the clinical utility of targeted next-generation sequencing among patients with cancers of unknown primary (CUP). The results showed that NGS testing provided treatment options for the majority of patients and assisted in identifying the likely primary tumor type in a clinically significant subset of patients.
Background Cancer of unknown primary (CUP) comprises a heterogeneous collection of malignancies that are typically associated with a poor prognosis and a lack of effective treatment options. We retrospectively evaluated the clinical utility of targeted next-generation sequencing (NGS) among CUP patients to assist with diagnosis and identify opportunities for molecularly guided therapy. Patients and Methods Patients with a CUP at Moffitt Cancer Center who underwent NGS between January 1, 2014 and December 31, 2019, were eligible for study inclusion. Next-generation sequencing results were assessed to determine the frequency of clinically actionable molecular alterations, and chart reviews were performed to ascertain the number of patients receiving molecularly guided therapy. Results Ninety-five CUP patients were identified for analysis. Next-generation sequencing testing identified options for molecularly guided therapy for 55% (n = 52) of patients. Among patients with molecularly guided therapy options, 33% (n = 17) were prescribed a molecularly guided therapy. The median overall survival for those receiving molecularly guided therapy was 23.6 months. Among the evaluable patients, the median duration of treatment for CUP patients (n = 7) receiving molecular-guided therapy as a first-line therapy was 39 weeks. The median duration of treatment for CUP patients (n = 8) treated with molecularly guided therapy in the second- or later-line setting was 13 weeks. Next-generation sequencing results were found to be suggestive of a likely primary tumor type for 15% (n = 14) of patients. Conclusion Next-generation sequencing results enabled the identification of treatment options in a majority of patients and assisted with the identification of a likely primary tumor type in a clinically meaningful subset of patients. Cancers of unknown primary are associated with poor prognosis and few effective treatment options. This article evaluates the clinical utility of targeted next-generation sequencing among patients with cancers of unknown primary.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据