相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Mitochondrial NAD(P)+ Transhydrogenase: From Molecular Features to Physiology and Disease
Annelise Francisco et al.
ANTIOXIDANTS & REDOX SIGNALING (2022)
A vaccine targeting mutant IDH1 in newly diagnosed glioma
Michael Platten et al.
NATURE (2021)
Energy Metabolism in IDH1 Wild-Type and IDH1-Mutated Glioblastoma Stem Cells: A Novel Target for Therapy?
Cornelis J. F. van Noorden et al.
CELLS (2021)
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
David N. Louis et al.
NEURO-ONCOLOGY (2021)
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
Luciano Garofano et al.
NATURE CANCER (2021)
Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
Grace H. McGregor et al.
CANCER RESEARCH (2020)
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
Justin A. Caravella et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
Zenon Konteatis et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Metabolic reprogramming and cancer progression
Brandon Faubert et al.
SCIENCE (2020)
Ivosidenib in Isocitrate Dehydrogenase 1-Mutated Advanced Glioma
Ingo K. Mellinghoff et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
Kristell Oizel et al.
CANCER & METABOLISM (2020)
Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide
Alex Shimura Yamashita et al.
NEURO-ONCOLOGY (2019)
The landscape of the mesenchymal signature in brain tumours
Jinan Behnan et al.
BRAIN (2019)
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
Felipe J. Nunez et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
Danielle Golub et al.
FRONTIERS IN ONCOLOGY (2019)
Genetic and molecular epidemiology of adult diffuse glioma
Annette M. Molinaro et al.
NATURE REVIEWS NEUROLOGY (2019)
Pharmacologic Targeting of Hypoxia-Inducible Factors
Gregg L. Semenza
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)
IDH3α regulates one-carbon metabolism in glioblastoma
Jasmine L. May et al.
SCIENCE ADVANCES (2019)
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
Edoardo Gaude et al.
MOLECULAR CELL (2018)
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Janeta Popovici-Muller et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2
Rui Ma et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Glutamate and α-ketoglutarate: key players in glioma metabolism
Andreas Maus et al.
AMINO ACIDS (2017)
Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis
Daniel R. Wahl et al.
CANCER RESEARCH (2017)
Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor
Young Shin Cho et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
Andrea E. Calvert et al.
CELL REPORTS (2017)
Altered metabolic landscape in IDH-mutant gliomasaffects phospholipid, energy, and oxidative stress pathways
Fred Fack et al.
EMBO MOLECULAR MEDICINE (2017)
Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity
Kristell Oizel et al.
CLINICAL CANCER RESEARCH (2017)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Qianghu Wang et al.
CANCER CELL (2017)
Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair
Yanxin Lu et al.
CANCER RESEARCH (2017)
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo
Stefan Pusch et al.
ACTA NEUROPATHOLOGICA (2017)
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
Satoshi Inoue et al.
CANCER CELL (2016)
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance
Monika D. Polewski et al.
MOLECULAR CANCER RESEARCH (2016)
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Lei Jiang et al.
NATURE (2016)
Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium
Jianhai Du et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
A Phase I Study of IDH305 in Patients with Advanced Malignancies Including Relapsed/Refractory AML and MDS That Harbor IDH1R132 Mutations
Courtney D. DiNardo et al.
BLOOD (2016)
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
Saverio Tardito et al.
NATURE CELL BIOLOGY (2015)
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
Ujunwa C. Okoye-Okafor et al.
NATURE CHEMICAL BIOLOGY (2015)
Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents
Pu Wang et al.
CELL REPORTS (2015)
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
Serena Pellegatta et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Bryce W. Carey et al.
NATURE (2015)
IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
Alexandra R. Grassian et al.
CANCER RESEARCH (2014)
Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and D-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia
Zachary J. Reitman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
A vaccine targeting mutant IDH1 induces antitumour immunity
Theresa Schumacher et al.
NATURE (2014)
IDH1 regulates phospholipid metabolism in developing astrocytes
Elena Bogdanovic et al.
NEUROSCIENCE LETTERS (2014)
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation
Fumiharu Ohka et al.
TUMOR BIOLOGY (2014)
Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
Andrew R. Mullen et al.
CELL REPORTS (2014)
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
Simran S. Sabharwal et al.
NATURE REVIEWS CANCER (2014)
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P. L. Bhat et al.
CANCER CELL (2013)
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
Martje Toenjes et al.
NATURE MEDICINE (2013)
An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
Dan Rohle et al.
SCIENCE (2013)
Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
Fang Wang et al.
SCIENCE (2013)
Sugar for the brain: the role of glucose in physiological and pathological brain function
Philipp Mergenthaler et al.
TRENDS IN NEUROSCIENCES (2013)
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
Alexandra Borodovsky et al.
ONCOTARGET (2013)
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
Sevin Turcan et al.
ONCOTARGET (2013)
The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma
Lee A. D. Cooper et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
RNA interference targeting cytosolic NADP+-dependent isocitrate dehydrogenase exerts anti-obesity effect in vitro and in vivo
Woo Suk Nam et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)
Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications
Liuqi Yang et al.
EXPERIMENTAL CELL RESEARCH (2012)
Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis
Donald D. Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation
Roberta Leonardi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen et al.
NATURE (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu et al.
NATURE (2012)
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan et al.
NATURE (2012)
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Masato Sasaki et al.
NATURE (2012)
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo
Janeta Popovici-Muller et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Sophia Y. Lunt et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
Fonnet E. Bleeker et al.
ACTA NEUROPATHOLOGICA (2010)
Hypoxia inducible factors in cancer stem cells
J. M. Heddleston et al.
BRITISH JOURNAL OF CANCER (2010)
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward et al.
CANCER CELL (2010)
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Maria E. Figueroa et al.
CANCER CELL (2010)
Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
Zachary J. Reitman et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)
Does the existing standard of care increase glioblastoma energy metabolism?
Thomas N. Seyfried et al.
LANCET ONCOLOGY (2010)
Quiescent Fibroblasts Exhibit High Metabolic Activity
Johanna M. S. Lemons et al.
PLOS BIOLOGY (2010)
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Roger Stupp et al.
LANCET ONCOLOGY (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
D. A. Tennant et al.
ONCOGENE (2009)
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Shimin Zhao et al.
SCIENCE (2009)
Detailed kinetics and regulation of mammalian NAD-linked isocitrate dehydrogenase
Feng Qi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line
Hyuntae Yoo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
An integrated genomic analysis of human glioblastoma Multiforme
D. Williams Parsons et al.
SCIENCE (2008)
The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist
Ryan J. Mailloux et al.
PLOS ONE (2007)
Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia
Ed R. Blazek et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism
HJ Koh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Reverse flux through cardiac NADP+-isocitrate dehydrogenase under normoxia and ischemia
B Comte et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase
P Lee et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase
SH Jo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)