The Historical Evolution of Ocular Tuberculosis: Past, Present, and Future

Ocular involvement is a rare manifestation of tuberculosis. Four key issues historically faced by clinicians when diagnosing and treating ocular tuberculosis - diagnostic uncertainty, naturally heterogeneous presentations, limitations of existing laboratory diagnostic tools, and non-uniform treatment guidelines - continue to test today's physicians. Unparalleled scientific and clinical developments over the past century have greatly expanded the knowledge surrounding this challenging ophthalmic condition. Experience with large volumes of cases at tuberculosis-endemic centres has led to recent growth in knowledge and physician experience, perhaps more so in developing countries. Looking forward, the role of diverse new technologies, including artificial intelligence and proteomics, will advance ocular tuberculosis research. Efforts have been made to address the lack of standardized nomenclature, diagnostic uncertainty, and unvalidated, geographically variable treatment guidelines.

Automated summary

Ocular involvement in tuberculosis presents challenges such as diagnostic uncertainty, heterogeneous presentations, limitations in laboratory tools, and non-uniform treatment guidelines. Recent advancements in scientific and clinical knowledge, particularly in tuberculosis-endemic countries, have helped improve understanding and experience with this condition. Future research in ocular tuberculosis may benefit from new technologies like artificial intelligence and proteomics to address issues such as standardized nomenclature and treatment guidelines.