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High-fat diets on the enteric nervous system: Possible interactions and mechanisms underlying dysmotility

期刊

OBESITY REVIEWS
卷 23, 期 4, 页码 -

出版社

WILEY
DOI: 10.1111/obr.13404

关键词

dysmotility; enteric nervous system; enteric neuroplasticity; high-fat diet

资金

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
  2. State of Rio de Janeiro Carlos Chagas Filho Research Foundation (FAPERJ) [E-26/203.269/2017]

向作者/读者索取更多资源

Obesity is a chronic disease that mainly affects the gastrointestinal tract, causing dysmotility. Studies on high-fat diet models have highlighted the impact of neuroplasticity on gut dysmotility. Various components of the gut environment, such as gut microbiota and inflammation, may influence enteric neuroplasticity.
Obesity is a chronic disease that affects various physiological systems. Among them, the gastrointestinal tract appears to be a main target of this disease. High-fat diet (HFD) animal models can help recapitulate the classic signs of obesity and present a series of gastrointestinal alterations, mainly dysmotility. Because intestinal motility is governed by the enteric nervous system (ENS), enteric neurons, and glial cells have been studied in HFD models. Given the importance of the ENS in general gut physiology, this review aims to discuss the relationship between HFD-induced neuroplasticity and gut dysmotility observed in experimental models. Furthermore, we highlight components of the gut environment that might influence enteric neuroplasticity, including gut microbiota, enteric glio-epithelial unit, serotonin release, immune cells, and disturbances such as inflammation and oxidative stress.

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