期刊
OBESITY REVIEWS
卷 23, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/obr.13377
关键词
biotin; gut microbiota; obesity; vitamins
资金
- Seventh Framework Programme [HEALTH-F4-2012-305312 METACARDIS]
- Fondation pour la Recherche Medicale [FDT201904008276, FDT202106012793]
- European Commission
- Leducq Foundation
Vitamins play a crucial role in obesity and related metabolic disorders, with some being synthesized and absorbed by the gut bacteria. Vitamin deficiency can lead to serious health issues, highlighting the importance of monitoring the vitamin status of obese patients and examining alterations in gut microbiota.
There are numerous factors involved in obesity progression and maintenance including systemic low-grade inflammation, adipose tissue dysfunction, or gut microbiota dysbiosis. Recently, a growing interest has arisen for vitamins' role in obesity and related disorders, both at the host and gut bacterial level. Indeed, vitamins are provided mostly by food, but some, from the B and K groups in particular, can be synthesized by the gut bacterial ecosystem and absorbed in the colon. Knowing that vitamin deficiency can alter many important cellular functions and lead to serious health issues, it is important to carefully monitor the vitamin status of patients with obesity and potentially already existing comorbidities as well as to examine the dysbiotic gut microbiota and thus potentially altered bacterial metabolism of vitamins. In this review, we examined both murine and human studies, to assess the prevalence of sub-optimal levels of several vitamins in obesity and metabolic alterations. This review also examines the relationship between vitamins and the gut microbiota in terms of vitamin production and the modulation of the gut bacterial ecosystem in conditions of vitamin shortage or supplementation. Furthermore, some strategies to improve vitamin status of patients with severe obesity are proposed within this review.
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