4.4 Review

Mitochondrial dysfunction and epigenetics underlying the link between early-life nutrition and non-alcoholic fatty liver disease

期刊

NUTRITION RESEARCH REVIEWS
卷 -, 期 -, 页码 -

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954422422000038

关键词

Early-life nutrition; Epigenetics; Mitochondria; Developmental programming; NAFLD

向作者/读者索取更多资源

Early-life malnutrition has a critical impact on fetal development and can lead to metabolic diseases later in life. Imbalances in early nutrition have been associated with long-term metabolic disorders, affecting mitochondrial function and epigenetic mechanisms. Consequently, mitochondrial dysfunction, epigenetic alterations, and early-life nutrition are important contributing factors in the pathogenesis of NAFLD.
Early-life malnutrition plays a critical role in foetal development and predisposes to metabolic diseases later in life, according to the concept of 'developmental programming'. Different types of early nutritional imbalance, including undernutrition, overnutrition and micronutrient deficiency, have been related to long-term metabolic disorders. Accumulating evidence has demonstrated that disturbances in nutrition during the period of preconception, pregnancy and primary infancy can affect mitochondrial function and epigenetic mechanisms. Moreover, even though multiple mechanisms underlying non-alcoholic fatty liver disease (NAFLD) have been described, in the past years, special attention has been given to mitochondrial dysfunction and epigenetic alterations. Mitochondria play a key role in cellular metabolic functions. Dysfunctional mitochondria contribute to oxidative stress, insulin resistance and inflammation. Epigenetic mechanisms have been related to alterations in genes involved in lipid metabolism, fibrogenesis, inflammation and tumorigenesis. In accordance, studies have reported that mitochondrial dysfunction and epigenetics linked to early-life nutrition can be important contributing factors in the pathogenesis of NAFLD. In this review, we summarise the current understanding of the interplay between mitochondrial dysfunction, epigenetics and nutrition during early life, which is relevant to developmental programming of NAFLD.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据