期刊
NUTRITION & METABOLISM
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12986-021-00622-8
关键词
Quinoa; Endoplasmic reticulum stress; Glycolipid metabolism; High-fat diet-induced obesity; Oxidative stress
资金
- National Natural Science Foundation of China [81774171]
- Horizontal subject of Zhong Fu Boai Health management (Beijing) Co., Ltd [2180071720024]
- Tangshan Science and Technology Innovation Team Training Program [19130201C]
The quinoa diet significantly reduced blood glucose, triglyceride, cholesterol, and low-density lipoprotein levels, improved glucose tolerance, and histological changes in liver tissues in obese mice. Additionally, quinoa improved oxidative stress indicators and down-regulated ER stress markers in the liver of obese mice.
Objective To explore the effects of the quinoa diet on glycolipid metabolism and endoplasmic reticulum (ER) stress in an obese mouse model. Methods Six-week-old C57BL/6J female mice have received a high-fat diet (HFD) to induce obesity and subsequently were treated with a quinoa diet for 12 weeks. During this period, fasting blood glucose, body fat and insulin resistance were measured regularly. At the end of the experiment, mouse serum and liver tissue were collected. The differences in glucose and lipid metabolism were analyzed, and liver tissue pathological morphology, liver endoplasmic reticulum stress-related mRNA and protein levels, and serum oxidative stress levels were measured. Results Quinoa diet could significantly reduce the level of blood glucose, triglyceride, cholesterol, low-density lipoprotein, improve glucose tolerance, as well as improve histological changes of liver tissues in obese mice (P < 0.05 or < 0.01). Besides, quinoa could improve oxidative stress indicators such as GSH, and MDA (P < 0.05 or < 0.01). Furthermore, quinoa can down-regulate mRNA expression of ER stress markers eIF2 alpha, GRP78, and CHOP in the liver of obese mice (P < 0.05 or < 0.01). Conclusions Quinoa supplementation can improve glycolipid metabolism, regulate ER stress, and alleviate obesity in HFD-induced mice.
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