4.8 Article

H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function

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Summary: Research reveals that ISW1b primarily regulates nucleosome spacing and resolution of closely packed dinucleosomes, with ISW1a playing a minor role. ISW1b and Chd1 make additive contributions to dinucleosome resolution. Set2-mediated H3-K36 trimethylation contributes to ISW1b-mediated dinucleosome separation.

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