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Article
Biochemistry & Molecular Biology
Eric W. Sayers et al.
Summary: The National Center for Biotechnology Information (NCBI) offers a wide range of online resources for biological information and data, including GenBank (R) nucleic acid sequence database and PubMed (R) database of citations and abstracts. Entrez system allows search and retrieval operations for most of these data, with E-utilities serving as the programming interface. Additional resources such as PMC, Bookshelf, Genome Data Viewer, SRA, ClinVar, dbSNP, dbVar, Pathogen Detection, BLAST, Primer-BLAST, IgBLAST, iCn3D, and PubChem are also accessible through the NCBI home page.
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Biochemistry & Molecular Biology
Wenjun Li et al.
Summary: The RefSeq project at NCBI contains a vast number of bacterial and archaeal genomes and proteins, with a focus on reducing spurious annotation through the use of expanded protein family models. The Protein Family Models Entrez database provides users with access to the PFMs, supporting multi-genome analyses and connections to the literature. The reference and representative genome set of prokaryotic genomes within RefSeq is regularly recalculated and available for download and BLAST searches.
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(2021)
Article
Biochemistry & Molecular Biology
Eric W. Sayers et al.
Summary: GenBank® is a comprehensive public database containing over 2.1 billion nucleotide sequences from 478,000 formally described species. Recent updates include new resources for data from the SARS-CoV-2 virus, updated submission portal and wizards, new taxonomy queries, and simplified submission processes for EST and GSS sequences.
NUCLEIC ACIDS RESEARCH
(2021)
Letter
Biochemistry & Molecular Biology
Mose Manni et al.
Summary: The BUSCO software provides essential methods for assessing the quality of genomic and metagenomic data, offering new functionalities and improvements to streamline the process. It is capable of evaluating both eukaryotic and prokaryotic species, and can be used across various data types including genome assemblies, metagenomic bins, transcriptomes, and gene sets.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biotechnology & Applied Microbiology
Kenneth S. Katz et al.
Summary: The study introduces a new tool, STAT, for fast taxonomic diversity assessment of submissions to NCBI, independent of metadata. The tool is accurate, reliable, and scalable, providing a reliable criteria for data selection by the scientific community, while also enhancing the submission metadata with taxonomic terms.
Article
Biochemistry & Molecular Biology
Asami Fukuda et al.
Summary: The DDBJ Center provides diverse biological databases and the NIG supercomputer for life sciences research. Collaborating with NCBI, EBI, and NBDC, it manages nucleotide sequences and human genotype-phenotype data.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Peter W. Harrison et al.
Summary: The European Nucleotide Archive (ENA) has been dedicated to freely archiving and presenting global public sequencing data for nearly 40 years, benefiting the entire scientific community and accelerating global research efforts. In 2020, major developments to ENA services and content included the release of an updated ENA browser, modernization of the release process, and collaborations with specific research communities for data coordination.
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Article
Biochemistry & Molecular Biology
Masanori Arita et al.
Summary: The International Nucleotide Sequence Database Collaboration (INSDC) has been a core infrastructure for collecting and providing nucleotide sequence data and metadata for over 30 years. Collaboratively maintained by three partner organizations, INSDC benefits science and communities worldwide.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qingyu Chen et al.
Summary: Since the outbreak of the COVID-19 pandemic in 2020, there has been a significant increase in articles related to COVID-19 and SARS-CoV-2. LitCovid, as the first COVID-19-specific literature resource, provides freely accessible curated articles and information, and has been widely used by users globally.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sunghwan Kim et al.
Summary: PubChem, a popular chemical information resource, has made substantial improvements in the past two years by adding data from over 100 new sources, updating its homepage and record pages, introducing new services like the Periodic Table and Pathway pages, and creating a special data collection related to COVID-19 and SARS-CoV-2 in response to the pandemic.
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