Demystifying solid targets: Simple and rapid distribution-scale production of [68Ga]GaCl3 and [68Ga]Ga-PSMA-11

Article Chemistry, Inorganic & Nuclear

Cyclotron-produced 68Ga from enriched 68Zn foils

Jonathan Siikanen et al.

Summary: The study focuses on the growing demand and limited availability of 68Ga for PET scans, proposing an alternative high-output production method using PET cyclotrons, and aims to expand production capacity by using enriched 68Zn foils.

APPLIED RADIATION AND ISOTOPES (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

68Ga-PSMA-11 NDA Approval: A Novel and Successful Academic Partnership

Giuseppe Carlucci et al.

Summary: This article discusses the collaboration between UCLA and UCSF in developing the new drug Ga-68-PSMA-11 for prostate cancer PET imaging, the FDA approval process, and key CMC information provided for ANDA submission.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Multidisciplinary Sciences

66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26

Sara S. Rinne et al.

Summary: This study successfully produced gallium-66 for radiolabeling and investigated the imaging properties of gallium-66 labeled GRPR-antagonist for PET imaging of GRPR expression. The results demonstrated that the radiotracer could clearly visualize GRPR expression, but delayed imaging did not improve contrast.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

A Review of Accelerator-Produced Ga-68 with Solid Targets

Kaelyn V. Becker et al.

Summary: This review explores gallium-68 production strategies including accelerator target designs at various beam energies and intensities, as well as radiochemical separation techniques for isolating Ga-68. It also discusses the recovery of isotopically enriched target material from irradiated targets and the implications of these techniques for downstream radiolabeling applications.

CURRENT RADIOPHARMACEUTICALS (2021)

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Article Biochemistry & Molecular Biology

Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers

Emma Jussing et al.

Summary: By adding ascorbate in the purification process, the level of metal impurities in (GaCl3)-Ga-68 was significantly lowered, allowing for high-yield radiolabeling of clinically relevant DOTA-based tracers. The resulting Ga-68 eluate could be used for GMP-compliant syntheses, yielding radiochemically pure and stable products.

BIOMOLECULES (2021)

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Review Chemistry, Medicinal

[68Ga]Ga-PSMA-11: The First FDA-Approved 68Ga-Radiopharmaceutical for PET Imaging of Prostate Cancer

Ute Hennrich et al.

Summary: Radiotracers targeting prostate-specific membrane antigen (PSMA) are commonly used for PET imaging of prostate cancer, with the recent approval of [Ga-68]Ga-PSMA-11 by the FDA in 2020. This radiopharmaceutical combines a peptidomimetic compound with the radionuclide Ga-68, allowing specific imaging of PSMA-positive tumor cells and potential applications in therapy planning and treatment response evaluation.

PHARMACEUTICALS (2021)

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Article Chemistry, Medicinal

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

Helge Thisgaard et al.

Summary: In response to the increasing clinical demand for gallium-68, a high-yield, automated method has been developed for producing multi-Curie levels of [Ga-68]GaCl3 from solid zinc-68 targets. This method led to record-high purified gallium-68 activities and successful labelling of PSMA-11 and DOTATATE, showing promising results for clinical use in terms of quality control.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)

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Article Chemistry, Inorganic & Nuclear