期刊
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
卷 117, 期 -, 页码 40-45出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2021.09.008
关键词
Guanylyl cyclase; Nitric oxide; cGMP; VASP; Catalytic activity; Mesenteric arteries; Myography
资金
- yy
sGC is the main receptor for NO, catalyzing the production of cGMP to induce vasorelaxation and inhibit leukocyte and platelet aggregation. Enhancing cGMP levels or inhibiting cGMP breakdown can be used for the treatment of cardiovascular and pulmonary diseases.
Soluble guanylyl cyclase (sGC, also called GC1) is the main receptor for nitric oxide (NO) that catalyzes the production of the second messenger molecule, 3 ' 5 ' cyclic guanosine monophosphate (cGMP) leading to vasorelaxation, and inhibition of leukocyte recruitment and platelet aggregation. Enhancing cGMP levels, through sGC agonism or inhibition of cGMP breakdown via phosphodiesterase inhibition, has yielded FDA approval for several cGMP modifier therapies for treatment of cardiovascular and pulmonary diseases. While basic research continues to improve our understanding of cGMP signaling and as new therapies evolve to elevate cGMP levels, we provide a short methodological primer for measuring cGMP and cGMP-mediated vascular relaxation for investigators.
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