期刊
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
卷 117, 期 -, 页码 46-52出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2021.10.002
关键词
Nitric oxide; Nitrosyl iron complexes; Albumin; Monoamine oxidase; Cytochrome c oxidase; NO donors
The study demonstrates that BSA effectively stabilizes the TNIC complex, prolonging its role as an NO donor and inhibiting lipid peroxidation-induced oxidative stress. Additionally, TNIC-BSA was found to inhibit the catalytic activity of mitochondrial membrane-bound enzymes. These findings suggest the practical application of TNIC-BSA in combating socially significant diseases.
Nitric oxide (NO) mediates diverse physiological processes in living organisms. Small molecular NO donors usually lack stability and have a short half-life in human tissues, limiting the therapeutic application. The anionic tetranitrosyl iron complex with thiosulfate ligands (TNIC) is one of the most promising NO donors. This study shows that bovine serum albumin (BSA) can effectively stabilize the TNIC complex under aerobic (physiological) conditions, which contributes to its prolonged action as NO donor. Our results demonstrated that TNIC-BSA inhibits formation of TBARS - standard biomarker for the lipid peroxidation induced oxidative stress. Also, it was found that TNIC-BSA inhibits the catalytic activity of mitochondrial membrane-bound enzymes: cytochrome c oxidase and monoamine oxidase A. Together, these results demonstrate that, stabilization of TNIC with BSA opens up the possibility of its practical application in chemotherapy of socially significant diseases.
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