期刊
NEW ENGLAND JOURNAL OF MEDICINE
卷 386, 期 6, 页码 599-601出版社
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc2119641
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资金
- National Institutes of Health [R37AI64003, R01AI501111, R01AI78788, P01-AI138398-S1, 2U19AI111825]
- National Center for Advancing Translational Sciences (National Institutes of Health Clinical and Translational Science Award program) [UL1 TR001866]
- Shapiro-Silverberg Fund for the Advancement of Translational Research
Neutralization assays showed much lower omicron neutralization compared to Wuhan-hu-1 after two doses of mRNA vaccine, but individuals who received a booster vaccine or were vaccinated after recovering from Covid-19 exhibited high levels of omicron neutralization.
Omicron Neutralization after the Third Vaccine Dose Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over time showed much lower omicron neutralization than Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from persons vaccinated after recovery from Covid-19 and those who received a booster vaccine had high levels of omicron neutralization.
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