4.5 Article

Implications of IDH mutations on immunotherapeutic strategies for malignant glioma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

What is the burden of proof for tumor mutational burden in gliomas?

Mustafa Khasraw et al.

Summary: Pan-cancer approvals have shown benefits in treating solid tumors, but concerns arise about generalizability to other tumor types, especially in managing patients with gliomas and other CNS tumors. The undefined cutoff for TMB-H and inherent immunological differences between gliomas and other cancers are key factors to consider. Further caution should be exercised in applying recent approvals, particularly in CNS tumors.

NEURO-ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson et al.

Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.
Article Medicine, Research & Experimental

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice

Padma Kadiyala et al.

Summary: The study focuses on glioma subtypes harboring mIDH1, TP53, and ATRX inactivation. In a mouse model, inhibition of D-2HG in combination with radiation and temozolomide (IR/TMZ) led to increased survival and anti-glioma immunological memory, which was enhanced by anti-PDL1 immune checkpoint blockade resulting in complete tumor regression in 60% of mice. This combination strategy reduced T cell exhaustion and favored memory CD8(+) T cell generation.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Multidisciplinary Sciences

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Michael Platten et al.

Summary: Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma. The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II. An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses that are effective against IDH1(R132H)+ tumours.

NATURE (2021)

Article Oncology

The immune landscape of common CNS malignancies: implications for immunotherapy

Martina Ott et al.

Summary: Immunotherapy has shown remarkable therapeutic responses in treating various cancers, with exceptions like glioblastoma. Immune profiling of samples from central nervous system tumors and brain metastases has revealed fundamental differences in immune composition, providing guidance for novel immunotherapeutic strategies.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas

Mirco Friedrich et al.

Summary: The study identifies different states of myeloid cells in gliomas and demonstrates that IDH-mutant tumors re-educate infiltrating macrophages through tryptophan metabolism, resulting in the formation of an immunosuppressive microenvironment. This suggests that targeting tryptophan metabolism could be a potential immunotherapy strategy for IDH-mutant tumors.

NATURE CANCER (2021)

Article Oncology

IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice

Leland G. Richardson et al.

ONCOIMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Junfei Zhao et al.

NATURE MEDICINE (2019)

Editorial Material Oncology

(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas

Leland G. Richardson et al.

TRANSLATIONAL CANCER RESEARCH (2019)

Article Multidisciplinary Sciences

Longitudinal molecular trajectories of diffuse glioma in adults

Floris P. Barthel et al.

NATURE (2019)

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

Article Biochemistry & Molecular Biology

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

Lukas Bunse et al.

NATURE MEDICINE (2018)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Cell Biology

Mutant IDH1 regulates the tumor-associated immune system in gliomas

Nduka M. Amankulor et al.

GENES & DEVELOPMENT (2017)

Article Medicine, Research & Experimental

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomase

Gary Kohanbash et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Oncology

Correlation of immune phenotype with IDH mutation in diffuse glioma

Anna Sophie Berghoff et al.

NEURO-ONCOLOGY (2017)

Letter Medicine, General & Internal

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

Mark Yarchoan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Oncology

The Microenvironmental Landscape of Brain Tumors

Daniela F. Quail et al.

CANCER CELL (2017)

Review Neurosciences

The role of microglia and macrophages in glioma maintenance and progression

Dolores Hambardzumyan et al.

NATURE NEUROSCIENCE (2016)

Article Oncology

Extreme Vulnerability of IDH1 Mutant Cancers to NAD plus Depletion

Kensuke Tateishi et al.

CANCER CELL (2015)

Article Multidisciplinary Sciences

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

Brett E. Johnson et al.

SCIENCE (2014)

Article Medicine, General & Internal

IDH1 and IDH2 Mutations in Gliomas

Hai Yan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)