期刊
NEUROSCIENCE RESEARCH
卷 173, 期 -, 页码 44-53出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2021.05.012
关键词
Leptin; Brain; BrdU; Plasticity; Feeding
资金
- Japan Society for the Promotion of Science [16K07027, 19K06921]
- Grants-in-Aid for Scientific Research [16K07027, 19K06921] Funding Source: KAKEN
Astrocyte-like and tanycyte-like neural stem cells were found in the medulla oblongata of mice, with different responses to leptin and nutritional conditions. These NSCs are multipotent cells that can differentiate into various types of neural cells, with astrocyte-like NSCs being more affected by nutritional conditions.
Astrocyte-and tanycyte-like neural stem cells (NSCs) were recently detected in the area postrema (AP) and central canal (CC) of the adult medulla oblongata, respectively. The present study aimed to examine dynamical behaviors of the astrocyte-and tanycyte-like NSCs of the mouse medulla oblongata to leptin. The neurosphere assay identified astrocytes in the AP and tanycytes in the CC as NSCs based on their self-renewing neurospherogenic potential. Both NSCs in neurosphere cultures were multipotent cells that generate astrocytes, oligodendrocytes, and neurons. Astrocyte-like NSCs actively proliferated and tanycyte-like NSCs were quiescent under physiologically-relevant in vivo conditions. Chronic leptin treatment promoted proliferation of astrocyte-like NSCs in the AP both in vitro and in vivo. Leptin receptors were expressed in astrocyte-like, but not tanycyte-like NSCs. Food deprivation significantly diminished proliferation of astrocyte-like NSCs. Therefore, the present study indicates that proliferation of astrocyte-like, but not tanycyte-like NSCs is regulated by nutritional conditions. (c) 2021 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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