Epigenetic regulation in the neurogenic niche of the adult dentate gyrus

The adult dentate gyrus (DG) of the hippocampal formation is a specialized region of the brain that creates new adult-born neurons from a pool of resident adult neural stem and progenitor cells (aNSPCs) throughout life. These aNSPCs undergo epigenetic and epitranscriptomic regulation, including 3D genome interactions, histone modifications, DNA modifications, noncoding RNA mechanisms, and RNA modifications, to precisely control the neurogenic process. Furthermore, the specialized neurogenic niche also uses epigenetic mechanisms in mature neurons and glial cells to communicate signals to direct the behavior of the aNSPCs. Here, we review recent advances of epigenetic regulation in aNSPCs and their surrounding niche cells within the adult DG.

Automated summary

The adult dentate gyrus (DG) of the hippocampal formation generates new adult-born neurons from resident adult neural stem and progenitor cells (aNSPCs) through epigenetic regulation. The niche also utilizes epigenetic mechanisms in mature neurons and glial cells to direct the behavior of the aNSPCs.