4.4 Article

Role of cytokine and neurotrophic factors in nicotine addiction in the conditioned place preference paradigm

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NEUROSCIENCE LETTERS
卷 764, 期 -, 页码 -

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ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.136235

关键词

CPP; Nicotine; Inflammation; Neurotrophic factors; Reward

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  1. FAPEMIG
  2. CNPq
  3. CAPES

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The study aimed to evaluate the levels of inflammatory mediators and neurotrophic factors in key areas of the central nervous system of mice subject to nicotine-induced CPP. Nicotine induced place preference behavior and resulted in increased peripheral levels of IL-6 and IL-10 alongside increased hippocampal levels of NGF but decreased GDNF in mice. In the striatum, nicotine promoted a decrease in IL-1ss, IL-10 and GDNF levels.
The mechanisms involved in the maintenance of cigarette smoking and nicotine reward remain unclear. Immune response might play an important role in this context. Nicotine may induce both central and systemic inflam-matory responses as well as changes in the regulation of brain-derived neurotrophic factor (BDNF). The conditioned place preference (CPP) is a method used for the evaluation of nicotine-induced reward, reproducing nicotine-seeking behavior in humans. So far, there are no studies investigating the relationship between neu-roinflammation and nicotine-induced CPP. This study aimed to evaluate the levels of inflammatory mediators and neurotrophic factors in key areas of the central nervous system (CNS) of mice subject to nicotine-induced CPP. CPP was induced with an intraperitoneal administration of 0.5 mg/kg of nicotine in male Swiss mice, using an unbiased protocol. Control group received vehicle by the same route. The levels of cytokines, chemo-kines, and neurotrophic factors were measured using Enzyme-Linked Immunosorbent Assay (ELISA) in the brain after CPP test. As expected, nicotine induced place preference behavior. In parallel, we observed increased pe-ripheral levels of IL-6 and IL-10 alongside increased hippocampal levels of NGF but decreased GDNF in mice treated with nicotine compared to controls. In the striatum, nicotine promoted decrease of IL-1ss, IL-10 and GDNF levels, while the levels of all the mediators were similar between groups in the pre-frontal cortex. Our results provide evidence on the role of cytokines and neurotrophic factors in nicotine-induced CPP in mice.

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