期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 129, 期 -, 页码 269-281出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.07.002
关键词
Major depressive disorder; Anxiety disorders; Posttraumatic stress disorder; Comorbidities; Gray matter volume; Meta-analysis; Structural neuroimaging; Neurphyiatry
资金
- Adrian and Simone Frutiger Foundation
- NIHR
- Wellcome Trust
- Rio Hortega fellowship by the Carlos III Health Institute (ISCIII), Spain [CM15/000839]
- Recercaixa
- Spanish Ministry of Health
- Ministry of Science and Innovation (CIBERSAM)
- Strategic Plan for Health Research and Innovation (PERIS) 2016-2020
The study found unique gray matter volume characteristics for Major Depressive Disorder, Anxiety Disorders, and Posttraumatic Stress Disorder, as well as some common features. These results provide support for the differences in neural correlates among different psychological disorders.
The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.
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