The role of circular RNAs in neuropathic pain

Neuropathic pain (NP) results from a lesion or disease of the nervous system and accompanied by chronic pain, leading a serious public health issue and economic burden. In terms of the NP mechanisms remaining poorly understood, circular RNAs (circRNAs), owing to their high stability and evolutionary conservation, are expected to be used as potential therapeutic targets or diagnostic biomarkers. In this review, we concisely discuss the characteristics and biological functions of circRNAs. As emerging evidence we reviewed, deregulation of circRNAs (e.g., circ-Filip1l, circHIPK3, ciRS-7, circRNA.2837, circ-Ankib1 and circAnks1a) were involved in NP development. It suggested that specific circRNAs modulated through sponging their target miRNAs and thus regulated the homologous downstream mRNAs and proteins in neuropathic pain. These findings provide a theoretical basis for circRNAs use as biomarkers and therapeutic targets in neuropathic pain.

Automated summary

This review discusses the characteristics and functions of circRNAs in neuropathic pain. Through the review of emerging evidence, it is found that deregulation of circRNAs is involved in the development of neuropathic pain and they can modulate downstream gene expression by sponging miRNAs. These findings provide a theoretical basis for the use of circRNAs as biomarkers and therapeutic targets in neuropathic pain.