期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 131, 期 -, 页码 1027-1036出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.10.017
关键词
Posttraumatic stress disorder; fMRI; Resting-state; Functional connectivity; Brain networks; Meta-analysis
资金
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYJC21041]
- Clinical and Translational Research Fund of Chinese Academy of Medical Sciences [2021-I2M-CT-B-097]
Studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit decreased functional connectivity within the default mode network (DMN) and between the affective network (AN) and DMN, while hyperconnectivity between the affective network and somatomotor network (SMN), and between the DMN and SMN is specifically related to PTSD. These results emphasize the impact of trauma on alterations in intrinsic brain networks and highlight disease-associated network changes.
Posttraumatic stress disorder (PTSD) is associated with dysfunction in large-scale brain functional networks, as revealed by resting-state functional connectivity studies. However, it remains unclear which networks have been most consistently affected and, more importantly, what role disease and trauma may play in the disrupted functional networks. We performed a systematic review of studies exploring network alterations using seedbased functional connectivity analysis, comparing individuals with PTSD to controls in general as well as trauma-exposed or nonexposed controls specifically, and quantitative meta-analysis was conducted when the number of studies was appropriately high. We found that hypoconnectivity within the default-mode network (DMN) as well as between the affective network (AN) and DMN were specifically associated with traumatic experience. Additionally, hyperconnectivity between the AN and somatomotor network (SMN) and between the DMN and SMN were specifically related to PTSD. Our results emphasize the effect of trauma itself on alterations in intrinsic brain networks and highlight disease-associated network alterations, which may help us better understand the neural mechanisms of trauma and PTSD.
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