4.7 Article

Design and evaluation of thermo-responsive nasal in situ gelling system dispersed with piribedil loaded lecithin-chitosan hybrid nanoparticles for improved brain availability

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Rufinamide-Loaded Chitosan Nanoparticles in Xyloglucan-Based Thermoresponsive In Situ Gel for Direct Nose to Brain Delivery

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Summary: In this study, Rufinamide-loaded chitosan nanoparticles were formulated and suspended in a thermoresponsive polymer-tamarind seed xyloglucan solution to create a nasal in situ gel for direct nose to brain drug delivery. The optimized nanoparticle formulation had favorable characteristics, and the in situ gelling formulation showed promising results in terms of direct transport efficiency and percentage.

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