相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The ups and downs of alkyl-carbamates in epilepsy therapy: How does cenobamate differ?
Wolfgang Loescher et al.
EPILEPSIA (2021)
The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy
Karen S. Wilcox et al.
NEUROPHARMACOLOGY (2020)
Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats
Kyle E. Thomson et al.
EPILEPSIA (2020)
In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders
Morten Grupe et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options
Wolfgang Loescher et al.
PHARMACOLOGICAL REVIEWS (2020)
Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?
Michelle Guignet et al.
EPILEPSIA (2020)
Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development
Meir Bialer et al.
EPILEPSIA (2020)
TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward
Tomas R. Guilarte
PHARMACOLOGY & THERAPEUTICS (2019)
Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy
Fan Zhang et al.
FASEB JOURNAL (2019)
An Investigation into Retigabine (Ezogabine) Associated Dyspigmentation in Rat Eyes by MALDI Imaging Mass Spectrometry
M. Reid Groseclose et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2019)
Epilepsy
Orrin Devinsky et al.
NATURE REVIEWS DISEASE PRIMERS (2018)
Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies
Yinhao Violet Wu et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2018)
KCNQ-Encoded Potassium Channels as Therapeutic Targets
Vincenzo Barrese et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)
Modulation of Kv7 channels and excitability in the brain
Derek L. Greene et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy
Wolfgang Loescher et al.
EPILEPSY & BEHAVIOR (2017)
Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs
Wolfgang Loscher
NEUROCHEMICAL RESEARCH (2017)
The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)
John H. Kehne et al.
NEUROCHEMICAL RESEARCH (2017)
Epilepsy-associated genes
Jie Wang et al.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2017)
Targeting Kv7 channels in pain pathways
Ivan Rivera-Arconada et al.
ONCOTARGET (2017)
Current insight into the role of voltage-gated potassiumion channel 7 (Kv7) channels: an emerging therapy target against epilepsy
Yu Diao et al.
Neuropsychiatry (2017)
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
Jin-feng Yue et al.
ACTA PHARMACOLOGICA SINICA (2016)
Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?
Fei Li et al.
BIOCHEMISTRY (2016)
Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond
Wolfgang Loescher et al.
CNS DRUGS (2016)
Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies
Wolfgang Loescher
EPILEPSY RESEARCH (2016)
Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet
Michael A. Rogawski et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators
Manoj Kumar et al.
MOLECULAR PHARMACOLOGY (2016)
Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection
Eleonora Da Pozzo et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2015)
Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)
Meir Bialer et al.
EPILEPSY RESEARCH (2015)
Translating dosages from animal models to human clinical trials-revisiting body surface area scaling
Otis L. Blanchard et al.
FASEB JOURNAL (2015)
Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus
Bopanna I. Kalappa et al.
JOURNAL OF NEUROSCIENCE (2015)
The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders
Vladimir M. Milenkovic et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2015)
Pathway-driven discovery of epilepsy genes
Jeffrey Noebels
NATURE NEUROSCIENCE (2015)
Translocator protein mediates the anxiolytic and antidepressant effects of midazolam
Zhi-Kun Qiu et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)
Genetic background of mice strongly influences treatment resistance in the 6 Hz seizure model
Karine Leclercq et al.
EPILEPSIA (2015)
The role of allopregnanolone in depression and anxiety
Cornelius Schuele et al.
PROGRESS IN NEUROBIOLOGY (2014)
The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential
A. Boehlen et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Neuroactive steroids for the treatment of status epilepticus
Michael A. Rogawski et al.
EPILEPSIA (2013)
Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model
Marion Bankstahl et al.
EPILEPSY RESEARCH (2013)
Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)
Meir Bialer et al.
EPILEPSY RESEARCH (2013)
Role of neurosteroids in the anticonvulsant activity of midazolam
Ashish Dhir et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy
Martin J. Gunthorpe et al.
EPILEPSIA (2012)
The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use
Charles H. Large et al.
EPILEPSIA (2012)
Adverse effects of antiepileptic drugs (vol 11, pg 792, 2012)
P. Perucca et al.
LANCET NEUROLOGY (2012)
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models
Marion Bankstahl et al.
NEUROTOXICOLOGY (2012)
Adverse effects of antiepileptic drugs
Piero Perucca et al.
LANCET NEUROLOGY (2012)
FRESH FROM THE PIPELINE Ezogabine (retigabine)
Carl E. Stafstrom et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
Wolfgang Loescher
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2011)
N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy
George Amato et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy
Doodipala Samba Reddy
Frontiers in Endocrinology (2011)
Steroid profiling in preeclamptic women: evidence for aromatase deficiency
Alexandre Hertig et al.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2010)
Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models
Nicole M. Rowley et al.
EPILEPSY RESEARCH (2010)
Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis
Kazuhiro Tokuda et al.
JOURNAL OF NEUROSCIENCE (2010)
Key factors in the discovery and development of new antiepileptic drugs
Meir Bialer et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
Rainer Rupprecht et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Neural KCNQ (Kv7) channels
David A. Brown et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
Meir Bialer et al.
EPILEPSY RESEARCH (2009)
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site
Karen Padilla et al.
NEUROSCIENCE LETTERS (2009)
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy
Thomas Stoehr et al.
EPILEPSY RESEARCH (2007)
The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain
M Verleye et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2005)
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain
P Liere et al.
JOURNAL OF LIPID RESEARCH (2004)
Multiple-dose, linear, dose-proportional pharmacokinetics of retigabine in healthy volunteers
GM Ferron et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2002)
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy
ME Barton et al.
EPILEPSY RESEARCH (2001)
KCNQ potassium channels: physiology, pathophysiology, and pharmacology
J Robbins
PHARMACOLOGY & THERAPEUTICS (2001)
Neuronal KCNQ potassium channels: Physiology and role in disease
TJ Jentsch
NATURE REVIEWS NEUROSCIENCE (2000)