AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.

Automated summary

AMPARs play crucial roles in excitatory synaptic transmission and plasticity, with LTP depending on the accumulation of AMPARs at the postsynapse. Recent research has proposed an updated model of AMPAR trafficking and LTP, incorporating both intracellular and extracellular mechanisms.