期刊
NEUROPATHOLOGY
卷 42, 期 3, 页码 197-203出版社
WILEY
DOI: 10.1111/neup.12793
关键词
aged; brain neoplasms; ganglioglioma; proto-oncogene protein BRAF
资金
- Japanese Society for the Promotion of Science (KAKENHI) [21H03044, 21K09128, 20K09392, 20K17972, 19K17673]
- Research Grants of the Inamori Foundation
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Grants-in-Aid for Scientific Research [20K09392, 20K17972, 21H03044, 21K09128, 19K17673] Funding Source: KAKEN
This article presents a rare case of ganglioglioma grade 3 with H3 K27M mutation in an elderly man. The patient underwent tumor resection and received chemotherapy and radiotherapy.
The mutation p.K27M in H3F3A (H3 K27M mutation) is mainly detected in diffuse midline glioma. However, recent studies have demonstrated that H3 K27M mutation could also be observed in a subset of gangliogliomas. Importantly, most H3 K27-mutated ganglioglioma cases also harbor BRAF V600E mutation. Herein, we report a rare case of H3 K27M-mutated ganglioglioma grade 3 without BRAF mutation arising in the medial temporal lobe in an elderly man. A small biopsy specimen was sampled. The pathological diagnosis was diffuse astrocytoma. The tumor progressed gradually during an 18-month follow-up period. Gadolinium enhancement on magnetic resonance imaging was noted 36 months after the biopsy. The patient was referred to a hospital for tumor resection. Histological analysis of resected specimens led to a diagnosis of ganglioglioma grade 3 with H3 K27M mutation. The patient underwent concurrent temozolomide chemotherapy with radiotherapy. Although the patient's condition deteriorated after chemotherapy due to disease progression, he survived for more than 23 months after tumor resection. We present this rare case and discuss the involvement of H3 K27M mutation in ganglioglioma grade 3.
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