4.8 Article

Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Clinical Neurology

Diffusion imaging in Huntington's disease: comprehensive review

Carlos Estevez-Fraga et al.

Summary: Huntington's disease is a monogenic disorder with genetic testing allowing for investigation of brain changes from early stages, diffusion MRI can track microstructural anomalies decades before clinical onset, and different research approaches reveal a centrifugal pattern of white matter degeneration in HD.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Review Neurosciences

Axon guidance receptors: Endocytosis, trafficking and downstream signaling from endosomes

R. J. Pasterkamp et al.

Summary: The translation explains how axons navigate through the nervous system and the role of endosomes in intracellular signaling. It highlights the importance of endosome trafficking for axon guidance receptors and their localization for proper function and signaling pathways.

PROGRESS IN NEUROBIOLOGY (2021)

Article Neurosciences

Microtubules, actin and cytolinkers: how to connect cytoskeletons in the neuronal growth cone

Rita Pinto-Costa et al.

Summary: Cytolinkers play a crucial role in ensuring the integration of different cytoskeleton components in neurons, which is essential for proper function and connectivity of high order circuits. Several cytoskeleton regulatory proteins with actin-microtubule crosslinking activity have been identified as important players in axon outgrowth and guidance.

NEUROSCIENCE LETTERS (2021)

Article Multidisciplinary Sciences

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

Mehdi Eshraghi et al.

Summary: The study reveals that mHtt promotes ribosome stalling and inhibits protein synthesis in HD cells, with Fmrp being upregulated but not affecting protein synthesis or ribosome stalling. There are interactions between ribosomal proteins, translating ribosomes, and mHtt, leading to a widespread shift in ribosome occupancy and unique single-codon pauses on selected mRNA targets in HD cells. This mechanistic defect of ribosomal translocation during translation elongation can be exploited for HD therapeutics.

NATURE COMMUNICATIONS (2021)

Article Biochemical Research Methods

Proline: an efficient and user-friendly software suite for large-scale proteomics

David Bouyssie et al.

BIOINFORMATICS (2020)

Review Cell Biology

Mechanistic advances in axon pathfinding

Laura E. McCormick et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Review Neurosciences

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

Naoki Suzuki et al.

FRONTIERS IN NEUROSCIENCE (2020)

Article Clinical Neurology

Abnormal development of cerebellar-striatal circuitry in Huntington disease

Alexander Tereshchenko et al.

NEUROLOGY (2020)

Review Clinical Neurology

A Critical Review of White Matter Changes in Huntington's Disease

Chiara Casella et al.

MOVEMENT DISORDERS (2020)

Article Multidisciplinary Sciences

Huntington's disease alters human neurodevelopment

Monia Barnat et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Yasset Perez-Riverol et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemical Research Methods

DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics

Samuel Wieczorek et al.

BIOINFORMATICS (2017)

Article Multidisciplinary Sciences

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics

Mingyue Jin et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation

Sara Gallini et al.

CURRENT BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Regulation of mitotic spindle orientation: an integrated view

Florencia di Pietro et al.

EMBO REPORTS (2016)

Review Neurosciences

The Biology of Huntingtin

Frederic Saudou et al.

NEURON (2016)

Article Multidisciplinary Sciences

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease

Aldrin E. Molero et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease

Xiaobei Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Neurosciences

Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate

Yuan Ren et al.

NEURAL PLASTICITY (2016)

Article Cell Biology

Axon Dynamics during Neocortical Laminar Innervation

Randal A. Hand et al.

CELL REPORTS (2015)

Article Developmental Biology

Axonal Transcription Factors: Novel Regulators of Growth Cone-to-Nucleus Signaling

Sheng-Jian Ji et al.

DEVELOPMENTAL NEUROBIOLOGY (2014)

Article Neurosciences

Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex

Maria Molina-Calavita et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Neurosciences

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

Spencer U. McKinstry et al.

JOURNAL OF NEUROSCIENCE (2014)

Review Neurosciences

Proteomic identification of the molecular basis of mammalian CNS growth cones

Michihiro Igarashi

NEUROSCIENCE RESEARCH (2014)

Review Cell Biology

Cellular and molecular mechanisms underlying axon formation, growth, and branching

Tommy L. Lewis et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Medicine, Research & Experimental

Metabolic network as a progression biomarker of premanifest Huntington's disease

Chris C. Tang et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemical Research Methods

Proteomic characterization of Pseudomonas aeruginosa PAO1 inner membrane

Maria G. Casabona et al.

PROTEOMICS (2013)

Article Biochemistry & Molecular Biology

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis

Surya A. Reis et al.

HUMAN MOLECULAR GENETICS (2011)

Review Neurosciences

Development specification, and diversity of callosal projection neurons

Ryann M. Fame et al.

TRENDS IN NEUROSCIENCES (2011)

Article Cell Biology

The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance

Erik W. Dent et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Biochemistry & Molecular Biology

The JIP1 scaffold protein regulates axonal development in cortical neurons

Federico Dajas-Ballador et al.

CURRENT BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

VC Wheeler et al.

HUMAN MOLECULAR GENETICS (2002)