Clinical and neuroradiological correlates of sleep in myotonic dystrophy type 1

Abnormalities of sleep are common in myotonic dystrophy type 1 (DM1), but few previous studies have combined polysomnography with detailed clinical measures and brain imaging. In the present study, domiciliary polysomnography, symptom questionnaires and cognitive evaluation were undertaken in 39 DM1-affected individuals. Structural brain MRI was completed in those without contra-indication (n = 32). Polysomnograms were adequate for analysis in 36 participants. Sleep efficiency was reduced, and sleep architecture altered in keeping with previous studies. Twenty participants (56%) had moderate or severe sleep-disordered breathing (apnoea-hypopnoea index [AHI] >= 15). In linear modelling, apnoeas were positively associated with increasing age and male sex. AHI >= 15 was further associated with greater daytime pCO(2) and self-reported physical impairment, somnolence and fatigue. Percentage REM sleep was inversely associated with cerebral grey matter volume, stage 1 sleep was positively associated with occipital lobe volume and stage 2 sleep with amygdala volume. Hippocampus volume was positively correlated with self-reported fatigue and somnolence. Linear relationships were also observed between measures of sleep architecture and cognitive performance. Findings broadly support the hypothesis that changes in sleep architecture and excessive somnolence in DM1 reflect the primary disease process in the central nervous system. (c) 2022 The Authors. Published by Elsevier B.V.

Automated summary

This study conducted comprehensive sleep monitoring on 39 DM1 patients and found that their sleep efficiency was reduced and sleep architecture was altered. Moderate or severe sleep-disordered breathing was also observed. Furthermore, sleep architecture and sleep quality were associated with brain structure and cognitive performance.