4.5 Review

Antioxidant therapies in traumatic brain injury

期刊

NEUROCHEMISTRY INTERNATIONAL
卷 152, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2021.105255

关键词

Traumatic brain injury; Oxidative stress; Free radicals; Antioxidants; Inflammation; Neuroprotection

资金

  1. US Department of Veterans Affairs (VA) [IK6BX005690]
  2. VA Merit Review Grant [I01BX004344]

向作者/读者索取更多资源

Oxidative stress plays a crucial role in the pathogenesis of traumatic brain injury, leading to cell death and secondary brain damage. Antioxidant therapies show promising outcomes in reducing damage and promoting functional recovery.
Oxidative stress plays a crucial role in traumatic brain injury (TBI) pathogenesis. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI synergistically contribute to secondary brain damage together with lipid peroxidation products (reactive aldehydes) and inflammatory mediators. Furthermore, oxidative stress, endoplasmic reticulum stress and inflammation potentiate each other. Following TBI, excessive oxidative stress overloads the endogenous cellular antioxidant system leading to cell death. To combat oxidative stress, several antioxidant therapies were tested in preclinical animal models of TBI. These include free radical scavengers, activators of antioxidant systems, Inhibitors of free radical generating enzymes and antioxidant enzymes. Many of these therapies showed promising outcomes including reduced edema, blood-brain barrier (BBB) protection, smaller contusion volume, and less inflammation. In addition, many antioxidant therapies also promoted better sensory, motor, and cognitive functional recovery after TBI. Overall, preventing oxidative stress is a viable therapeutic option to minimize the secondary damage and to improve the quality of life after TBI.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据