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Biochemistry & Molecular Biology
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Summary: Pomegranate extract can induce antidepressant-like effects when administered orally or intraperitoneally, with involvement of ER beta and the serotonergic system.
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NEUROCHEMISTRY INTERNATIONAL
(2021)
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Ahilya Singh et al.
Summary: Neuroinflammation is a complex response to brain injury involving the activation of glia, release of inflammatory mediators, and generation of reactive oxygen and nitrogen species. Anti-inflammatory compounds sourced from plants, particularly those classified as cytokine-suppressive anti-inflammatory drugs, have shown potential in the treatment of neurodegenerative diseases. Australian plants offer a diverse source of chemical compounds with anti-inflammatory properties due to their response to various stresses in their environment.
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Yue Liu et al.
Summary: Supplementation with gamma-GC decreased brain lipid peroxidation, protein carbonyls, and apoptosis, while increasing total GSH levels and enhancing antioxidant enzyme activities. Additionally, gamma-GC improved Aβ pathology and cognitive function in APP/PS1 mice.
NEUROCHEMISTRY INTERNATIONAL
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Psychiatry
Jerome Sarris et al.
Summary: Plant-based medicines have been used in the treatment of psychiatric disorders for a long time, and recent meta-analyses have examined the efficacy of several plant-based medicines. The findings suggest that some plant-based medicines may have certain effects in treating depression and schizophrenia, but more rigorous international studies are needed to confirm their efficacy.
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Kei-Lin Murata Ooi et al.
Summary: This article discusses the role of lipids in the brain, changes in lipid profiles in aging and Alzheimer's disease, the potential of lipid-based nutraceuticals to improve cognitive impairment, and various research directions such as dietary intake of lipids, modulation of gut microbiota, and manipulation of pathways involved in lipid metabolism.
NEUROCHEMISTRY INTERNATIONAL
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Biochemistry & Molecular Biology
Ashish Kumar et al.
Summary: The brain and neuronal circuits are the most complex organ networks in the human body and are highly influenced by stress, lifestyle, and age. Nutritional remediation of brain dysfunctions primarily through nutraceuticals and specific dietary patterns can promote brain health. Herbs and their phytochemicals with neuro-nutraceutical potentials have gained remarkable attention for their wide range of biological and pharmacological activities in improving cognitive function and providing antioxidant and anti-inflammatory effects.
NEUROCHEMISTRY INTERNATIONAL
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Biochemistry & Molecular Biology
Raju Dash et al.
Summary: This article discusses the relationship between proteostasis and proteinopathies, as well as the effectiveness of using phytochemicals to modulate proteostasis. Modulating proteostasis targeting proteinopathies may be an effective way to prevent the progression of neurodegenerative diseases.
NEUROCHEMISTRY INTERNATIONAL
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Biochemistry & Molecular Biology
Shreyasi Majumdar et al.
Summary: Asparagus racemosus, a well-known nutraceutical in ancient Greek, Chinese, and Ayurvedic medicine, is recognized for its potential neuroprotective, antioxidant, anti-inflammatory, and cognitive enhancement properties. However, the lack of standardization hinders its translation into an FDA-approved neuromedicine for neurological disorders.
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Biochemistry & Molecular Biology
Walter E. Mueller et al.
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Vaibhav Walia et al.
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Biochemistry & Molecular Biology
Manoj Govindarajulu et al.
Summary: Alzheimer's disease is the most common neurodegenerative disease with no effective treatment currently available. Dysfunctional SIRT3 is strongly associated with AD pathologies, suggesting therapeutic modulation of SIRT3 activity as a promising approach for improving the disease progression. Natural SIRT3 activators derived from traditional medicine show potential neuroprotective benefits for the treatment and management of neurodegenerative diseases like AD.
NEUROCHEMISTRY INTERNATIONAL
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Biochemistry & Molecular Biology
Md Abdul Hannan et al.
Summary: This study aimed to investigate the effects of Centella asiatica and its active component asiatic acid on various stages of neuronal polarity. The results showed that CAE enhanced neurite outgrowth, dendritic and axonal morphology, and facilitated synapse formation, indicating its neurotrophic function. Asiatic acid also promoted neurite outgrowth, but to a lesser extent compared to CAE.
NEUROCHEMISTRY INTERNATIONAL
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Biochemistry & Molecular Biology
Padmanabh Singh et al.
Summary: Cognitive abilities decline with age, posing a risk for the development of dementia and other brain disorders. Genetic susceptibility and environmental exposures determine the fate of cognitive aging and its progression to pathological states. Lifestyle factors, including dietary patterns and nutritional intake, are important in maintaining cognitive health and reducing the risk of neurodegenerative diseases.
NEUROCHEMISTRY INTERNATIONAL
(2021)
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Biochemistry & Molecular Biology
Harpal Singh et al.
Summary: The study demonstrated the potential of Tinospora cordifolia extract in mitigating anxiety, apoptosis, and neuroinflammation in high fat diet-induced obesity rat model. The extract showed modulation of inflammation, apoptosis, and synaptic plasticity in obese rats fed with high fat diet, suggesting its potential therapeutic value in managing obesity-related brain dysfunctions.
NEUROCHEMISTRY INTERNATIONAL
(2021)
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Biochemistry & Molecular Biology
Senthilkumar S. Karuppagounder et al.
Summary: Parkinson's disease is a progressive neurodegenerative disorder affecting over 10 million people worldwide, with oxidative stress and mitochondrial dysfunction playing key roles in its progression. Studies suggest that caffeine may improve neurological function in PD patients and potentially prevent disease progression.
NEUROCHEMISTRY INTERNATIONAL
(2021)
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Biochemistry & Molecular Biology
Yan-Ying Fan et al.
Summary: Astrocytes play a key role in maintaining CNS homeostasis and function, and can be activated into neurotoxic or neuroprotective phenotypes. Understanding different phenotypic astrocytes may lead to effective strategies for neurological disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
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Biochemistry & Molecular Biology
Yunna Kim et al.
Summary: The study showed that Lindera glauca can improve cognitive impairments induced by A beta(1-42), reduce pathological protein deposition, and promote neuroprotection.
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Biochemistry & Molecular Biology
V. Cardozo et al.
Summary: Hypoxic-ischemic encephalopathy (HIE) leads to mortality and long-term neurologic morbidities in newborns, involving energy failure, excitotoxicity, and oxidative stress. Quercetin has been shown to have neuroprotective effects in perinatal asphyxia models, reducing mortality and affecting protein expression. The glycolytic pathway is strongly regulated by quercetin in both rat and piglet models, indicating potential neuroprotective mechanisms.
NEUROCHEMISTRY INTERNATIONAL
(2021)
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Biochemistry & Molecular Biology
Farida El Gaamouch et al.
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative disease of aging, posing a major burden for patients, caregivers, and the healthcare system. Due to the complexity of AD pathophysiology and limited treatment options, there is a growing interest in the scientific community in exploring the impact of diet and nutrition on AD. Grape derived polyphenols are considered as potential novel strategies for AD treatment, showing promising results in modulating various aspects of AD pathophysiology.
NEUROCHEMISTRY INTERNATIONAL
(2021)
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Biochemistry & Molecular Biology
Rajat Sandhir et al.
Summary: Neem, an extensively used plant in the Indian traditional medical system, contains diverse phytochemicals with therapeutic activities like anti-viral, anti-cancer, and neuroprotective properties. Studies have shown the potential benefits of Neem compounds in treating neurological disorders such as Alzheimer's and Parkinson's disease, but further research on the molecular mechanisms is needed.
NEUROCHEMISTRY INTERNATIONAL
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Charles Elias Assmann et al.
Summary: Nutraceuticals have been the subject of extensive research in recent years, with some showing promise in promoting certain health benefits. Certain Amazonian fruits and seeds may have potential beneficial impacts on the human nervous system, possibly due to the presence of various bioactive molecules.
NEUROCHEMISTRY INTERNATIONAL
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Silvia A. Mandel et al.
CNS NEUROSCIENCE & THERAPEUTICS
(2008)