Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved

Article Neurosciences

Effects of aerobic exercise on hippocampal SUMOylation in APP/PS1 transgenic mice

Zhang Chenfei et al.

Summary: Exercise can improve learning and memory impairments in AD mice by reducing SUMO1 modification in the hippocampus, but has no significant effect on SUMO2/3 modification.

NEUROSCIENCE LETTERS (2022)

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Review Pharmacology & Pharmacy

Modulating role of serotonergic signaling in sleep and memory

Salar Vaseghi et al.

Summary: This review study discusses the role of serotonergic receptors in modulating the sleep-wake cycle, learning, and memory function, as well as the effects of sleep deprivation on memory function and its potential interaction with serotonin. There is inconsistency in the pattern of serotonergic function in sleep deprivation and it appears that serotonin may not have a definitive role in the effects of sleep deprivation on memory function. Factors such as the type of serotonergic agents, doses of drugs, and the regulation of serotonergic receptors during memory tasks training are important considerations in the effects of serotonergic signaling on sleep, memory, and sleep deprivation-induced memory impairments.

PHARMACOLOGICAL REPORTS (2022)

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Article Psychology, Biological

Effects of corticosterone on BDNF expression and mood behaviours in mice

Liying Lin et al.

Summary: Corticosterone can induce depressive-like and anxiety-like behaviors in mice, as well as differential changes in proBDNF and mBDNF in various brain regions and peripheral tissues. ProBDNF may participate in the development of depressive behaviors in corticosterone-treated animals.

PHYSIOLOGY & BEHAVIOR (2022)

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Article Rehabilitation

Treadmill exercise alleviates short-term memory impairments of pups born to old and obese mother rats

Young Jun Ko

Summary: Obesity can cause brain atrophy and memory issues, but maternal exercise has been found to improve short-term memory, reduce cell apoptosis, and increase new cell generation in offspring born to obese mothers. Therefore, maternal exercise may help reduce the health risks for fetuses born to old obese mothers.

JOURNAL OF EXERCISE REHABILITATION (2021)

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Article Rehabilitation

Treadmill exercise ameliorates impairment of spatial learning memory in pups born to old and obese mother rats

Sang-Hoon Kim et al.

Summary: The study showed that exercise during pregnancy of older and obese mothers can benefit the memory and immune system of offspring, improving spatial learning memory impairment, suppressing inflammation, reducing cytokine levels, and regulating the expression of apoptosis-related proteins in offspring.

JOURNAL OF EXERCISE REHABILITATION (2021)

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Article Immunology

Voluntary exercise ameliorates synaptic pruning deficits in sleep-deprived adolescent mice

Li-Heng Tuan et al.

Summary: Adolescence is a critical period for brain development, and lack of sleep can have detrimental effects on the neurological functions of adolescents. Voluntary exercise has been shown to protect microglial functions and improve neuronal abnormalities caused by sleep deprivation in adolescents.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Immunology

Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Francesca Romana Rizzo et al.

Summary: Exercise is recommended as a beneficial supportive therapy for people with MS, improving motor disability and pathological features. Chronic voluntary exercise has positive effects on motor disability, cognition, and hippocampal damage in an animal model of MS, by reducing inflammation, promoting synaptic plasticity, and protecting neurons. Overall, regular exercise improves cognitive function and brain pathology in EAE/MS.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Immunology

Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus

Maheedhar Kodali et al.

Summary: Moderate and intermittent physical exercise shows promise in improving cognitive and mood function in veterans with Gulf War Illness, while also suppressing neuroinflammation and enhancing hippocampal neurogenesis.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Developmental Biology

Acrobatic exercise recovers object recognition memory impairment in hypoxic-ischemic rats

Wellington de Almeida et al.

Summary: The study found that acrobatic exercises improved novel object recognition memory in hypoxia-ischemia rats, but spatial memory did not show significant improvement. Neuroplasticity markers in the hippocampus and striatum indicated plastic alterations, with exercise promoting functional recovery.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2021)

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Article Behavioral Sciences

Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats

Guoyuan Pan et al.

Summary: The study found that different intensities of treadmill training have varying effects on hippocampal synaptic plasticity in children after stroke, with medium-intensity training being the most effective in improving spatial cognitive abilities and neuron density. Treadmill training helps reduce neurobehavioral scores and cerebral infarction volumes.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Neurosciences

Aerobic exercise training decreases cognitive impairment caused by demyelination by regulating ROCK signaling pathway in aging mice

Chuncha Bao et al.

Summary: Recent studies show that aerobic exercise may protect myelin sheath in aged mice by regulating the ROCK signal pathway, improving memory and cognitive functions, reducing apoptosis, and promoting myelination.

BRAIN RESEARCH BULLETIN (2021)

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Article Medicine, Research & Experimental

Levetiracetam promoted rat embryonic neurogenesis via NMDA receptor-mediated mechanism in vitro

Mohaddeseh Sadat Alavi et al.

Summary: The study demonstrates that LEV can enhance the proliferation of rat embryonic neural stem cells and promote neuronal differentiation mainly through an NMDA receptor-mediated mechanism.

LIFE SCIENCES (2021)

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Review Geriatrics & Gerontology

Effects of physical exercise on the aging brain across imaging modalities: A meta-analysis of neuroimaging studies in randomized controlled trials

Lanxin Ji et al.

Summary: This study identifies consistent exercise-induced neuroplasticity in the hippocampus/parahippocampal area and cerebellum, highlighting the effectiveness of physical exercise in maintaining memory function in older adults. Specifically, changes in the medial/superior prefrontal cortex were associated with cognitive changes despite not reaching statistical significance.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2021)

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Article Endocrinology & Metabolism

Developmental regulation and lateralization of N-methyl-D-aspartate (NMDA) receptors in the rat hippocampus

Mostafa Peyvandi Karizbodagh et al.

Summary: The study found a marked right-left asymmetry in the expression of NR1 and NR2B subunits in the developing rat hippocampus, which might be considered as a probable mechanism for the lateral differences in the structure and function of the hippocampus in rats.

NEUROPEPTIDES (2021)

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Article Neurosciences

Mild regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on spatial memory

Leyla Sahin et al.

Summary: This study investigated the protective effects of mild treadmill exercise on acute sleep deprivation rats, finding that exercise can alleviate memory impairment but there is a lack of correlation between hippocampal gene expression levels and memory impairment.

BRAIN RESEARCH (2021)

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Article Cell Biology

HDAC inhibition prevents hypobaric hypoxia-induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway

Rahul Kumar et al.

Summary: Hypobaric hypoxia impairs cognitive function at higher altitudes, but treatment with sodium butyrate can alleviate this condition. Sodium butyrate increases BDNF expression, which in turn regulates neurodegeneration and memory loss, improving cognitive function in rats exposed to hypobaric hypoxia.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Voluntary wheel running is capable of improving cognitive function only in the young but not the middle-aged male APPSwe/PS1De9 mice

Guiping Wang et al.

Summary: The study found that voluntary wheel running improved cognitive function in young APP/PS1 mice through various mechanisms, such as reducing tau phosphorylation and neuro-inflammation, and increasing key synaptic plasticity-related proteins. For middle-aged APP/PS1 mice, voluntary exercise reduced protein expression in certain brain regions, but did not significantly affect circulating metabolites.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Psychology, Biological

Exercise preconditioning ameliorates cognitive impairment and anxiety-like behavior via regulation of dopamine in ischemia rats

Yongzhao Fan et al.

Summary: The study showed that pre-ischemic voluntary wheel running for 1 or 4 weeks can significantly increase the basal dopamine level, attenuate the increase of striatal dopamine induced by cerebral ischemia, and improve neurocognitive function in ischemia rats.

PHYSIOLOGY & BEHAVIOR (2021)

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Article Psychiatry

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease

Natalia M. Lyra e Silva et al.

Summary: Alzheimer's disease is associated with cognitive impairment and metabolic alterations, with mounting evidence suggesting that abnormal signaling in a brain-periphery metabolic axis plays a crucial role in its pathophysiology. The IL-6 pathway may serve as a key link between memory dysfunction and metabolic changes in AD. Targeting pro-inflammatory IL-6 signaling could be a strategy to alleviate memory impairment and metabolic alterations in the disease.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Behavioral Sciences

Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins

Gwo-Ching Sun et al.

Summary: Regular exercise has been shown to enhance neuroplasticity and improve functional outcomes after brain injuries. This study investigated the impact of prenatal DEHP exposure on hippocampal Arc expression and the protective role of exercise in male rats exposed to DEHP. The results demonstrated that DEHP exposure led to impaired spatial learning and memory, along with down-regulation of BDNF, NMDAR, Arc, and synaptophysin. However, aerobic exercise during childhood-adolescence prevented these impairments by restoring the expression of key proteins related to neuroplasticity.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Behavioral Sciences

Treadmill exercise overcomes memory deficits related to synaptic plasticity through modulating ionic glutamate receptors

Baixia Li et al.

Summary: The study investigated the association between exercise-ameliorated Alzheimer's disease with changes in ionic glutamate receptors, showing that 12-week treadmill exercise improved spatial learning and memory abilities of TgAPP/PS1 mice, reduced A beta levels in hippocampus and increased synaptic density and thickness.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Endurance exercise improves avoidance learning and spatial memory, through changes in genes of GABA and relaxin-3, in rats

Mahnaz Sinaei et al.

Summary: Submaximal aerobic exercise has significant effects on spatial memory, passive avoidance learning, and neurotransmitter levels in adult male Wistar rats. Specifically, it can improve memory and learning while decreasing relaxin-3 levels and affecting GABA and GAD65/67 genes.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Neurosciences

One single physical exercise session improves memory persistence by hippocampal activation of D1 dopamine receptors and PKA signaling in rats

Karine Ramires Lima et al.

Summary: The study demonstrates that D1/D5 agonists and a single session of physical exercise can enhance memory retention, while D1/D5 antagonists can impair the effects of exercise. Additionally, PKA inhibition affects the impact of acute physical exercise on memory, while PKC does not.

BRAIN RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice

Haizhen Yu et al.

Summary: This study demonstrates that aerobic treadmill exercise for APP/PS1 mice can enhance hippocampal neurogenesis by improving the microenvironment, promoting new cell proliferation and differentiation, ultimately leading to improved learning and memory capacity in Alzheimer's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Exercise intensities modulate cognitive function in spontaneously hypertensive rats through oxidative mediated synaptic plasticity in hippocampus

Cheng-Che Lee et al.

Summary: The study found that low-intensity exercise is more effective in improving cognitive function compared to high-intensity exercise, by reducing oxidative damage and enhancing synaptic plasticity in the hippocampus.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Behavioral Sciences

Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats

Fatemeh Sadat Zolfaghari et al.

Summary: This study shows that exercise and FLX treatment during adolescence can alleviate depressive and anxiety-like symptoms induced by maternal separation stress in adult male rats, while treadmill exercise has anxiolytic effects but fails to produce antidepressant-like effects.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2021)

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Article Environmental Sciences

Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats

Liyuan Xu et al.

Summary: The study demonstrated that a combination of exercise with an enriched environment significantly enhances learning and memory ability in rats, along with upregulating the expression of brain-derived neurotrophic factor and receptor tyrosine kinase B.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Psychiatry

Beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats

Kai Xiao et al.

Summary: Running exercise can alleviate symptoms of depression by reducing the number of microglia and inhibiting their activation in the hippocampus, leading to a decrease in neuroinflammation levels and improvement in depressive-like symptoms.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Clinical Neurology

Black Bamboo Rhizome Extract Improves Cognitive Dysfunction by Upregulating the Expression of Hippocampal BDNF and CREB in Rats with Cerebral Ischaemia-Reperfusion Injury

Chuan-An Yi et al.

Summary: Treatment with black bamboo rhizome extracts significantly improved cognitive dysfunction, reduced cerebral oedema, decreased the cerebral infarction area, and improved the neurological function score and learning and memory abilities in rats with cerebral ischaemia-reperfusion injury.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Article Urology & Nephrology

Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats

Sang-Hoon Kim et al.

Summary: The study demonstrated that treadmill running can improve spatial learning memory in Alzheimer's disease rats by suppressing proinflammatory cytokine production and apoptosis through inactivation of the NF-kappa B/MAPK signaling pathway.

INTERNATIONAL NEUROUROLOGY JOURNAL (2021)

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Article Rehabilitation

Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease

Sang-Hoon Kim et al.

Summary: Resistance exercise can improve short-term memory in PD patients by inhibiting the secretion of proinflammatory cytokines and inactivating NF-kappa B, similar to the effects of levodopa treatment.

JOURNAL OF EXERCISE REHABILITATION (2021)

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Article Neurosciences

Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats

Mona Faraz et al.

Summary: The study demonstrated that applying low frequency stimulation (LFS) in kindled animals improved spatial learning and memory, accompanied by changes in gene expression and protein levels. The improvements may be attributed to the prevention of kindling-induced alterations in gene expression by LFS intervention.

ACTA NEUROBIOLOGIAE EXPERIMENTALIS (2021)

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Article Cell Biology

D-serine reduces memory impairment and neuronal damage induced by chronic lead exposure

Jian-Zhu Bo et al.

Summary: Chronic lead exposure in rat models resulted in hippocampal injuries, but treatment with D-serine showed potential in alleviating pathological damage and restoring learning and memory impairments induced by lead exposure. The mechanism behind this effect involves increased expression of NR2A in the hippocampus.

NEURAL REGENERATION RESEARCH (2021)

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Article Endocrinology & Metabolism

Impact of different intensities of forced exercise on deficits of spatial and aversive memory, anxiety-like behavior, and hippocampal BDNF during morphine abstinence period in male rats

Azadeh Shahroodi et al.

METABOLIC BRAIN DISEASE (2020)

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Article Medicine, Research & Experimental

Treadmill exercise enhances the promoting effects of preconditioned stem cells on memory and neurogenesis in Aβ-induced neurotoxicity in the rats

Rokhsareh Abshenas et al.

LIFE SCIENCES (2020)

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Article Behavioral Sciences

Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus

Yulong Wu et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

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Article Neurosciences

One physical exercise session promotes recognition learning in rats with cognitive deficits related to amyloid beta neurotoxicity

Leticia Rossi Dare et al.

BRAIN RESEARCH (2020)

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Article Clinical Neurology

Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model

Idil Mitsadali et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Treadmill exercise restores memory and hippocampal synaptic plasticity impairments in ovalbumin-sensitized juvenile rats: Involvement of brain-derived neurotrophic factor (BDNF)

Amin Mokhtari-Zaer et al.

NEUROCHEMISTRY INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Dean-Chuan Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Behavioral Sciences

Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats

Ali Rashidy-Pour et al.

BEHAVIOURAL PHARMACOLOGY (2020)

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Article Geriatrics & Gerontology

Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression

Mostafa Sabouri et al.

EXPERIMENTAL GERONTOLOGY (2020)

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Article Behavioral Sciences

Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling

Nicolette A. Moya et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2020)

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Article Psychology, Biological

Effects of treadmill exercise on cognitive functions and anxiety-related behaviors in ovariectomized diabetic rats

Moslem Mohammadi et al.

PHYSIOLOGY & BEHAVIOR (2020)

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Article Psychology, Biological

Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease

Hamideh Bashiri et al.

PHYSIOLOGY & BEHAVIOR (2020)

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Article Neurosciences

Treadmill exercise ameliorates memory deficits and hippocampal inflammation in ovalbumin-sensitized juvenile rats

Amin Mokhtari-Zaer et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Rehabilitation

Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups

Young Jun Ko et al.

JOURNAL OF EXERCISE REHABILITATION (2020)

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Article Neurosciences

The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis

Ewelina Maliszewska-Cyna et al.

NEUROIMAGE (2020)

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Article Urology & Nephrology

Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats

Young Jun Ko et al.

INTERNATIONAL NEUROUROLOGY JOURNAL (2020)

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Article Behavioral Sciences

Brain-derived neurotropic factor and cortisol levels negatively predict working memory performance in healthy males

Luke Ney et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2020)

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Article Rehabilitation

Treadmill exercise in obese maternal rats during pregnancy improves short-term memory through neurogenesis in the hippocampus of rat pups

Eun-Sang Ji et al.

JOURNAL OF EXERCISE REHABILITATION (2020)

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Review Developmental Biology

Physical activity throughout pregnancy is key to preventing chronic disease

Taniya S. Nagpal et al.

REPRODUCTION (2020)

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Article Rehabilitation

Swimming exercise ameliorates mood disorder and memory impairment by enhancing neurogenesis, serotonin expression, and inhibiting apoptosis in social isolation rats during adolescence

Hye-Sang Park et al.

JOURNAL OF EXERCISE REHABILITATION (2020)

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Article Rehabilitation

Effects of treadmill exercise on activity, short-term memory, vascular dysfunction in maternal separation rats

Sang-Seo Park et al.

JOURNAL OF EXERCISE REHABILITATION (2020)

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Article Rehabilitation

Effects of swimming exercise on social isolation-induced memory impairment and apoptosis in old rats

Sang-Seo Park et al.

JOURNAL OF EXERCISE REHABILITATION (2020)

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Article Rehabilitation

Treadmill exercise ameliorates social isolation-induced memory impairment by enhancing silent information regulator-1 expression in rats

Tae-Woon Kim et al.

JOURNAL OF EXERCISE REHABILITATION (2020)

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Article Neurosciences

Differential effects of adolescent and adult-initiated exercise on cognition and hippocampal neurogenesis

James D. O'Leary et al.

HIPPOCAMPUS (2019)

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Article Neurosciences

Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways

Qingfeng Xie et al.

EXPERIMENTAL NEUROLOGY (2019)

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Article Anatomy & Morphology

The effect of exercise on memory and BDNF signaling is dependent on intensity

Marina Cefis et al.

BRAIN STRUCTURE & FUNCTION (2019)

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Article Neurosciences

The Influence of Hippocampal Dopamine D2 Receptors on Episodic Memory Is Modulated by BDNF and KIBRA Polymorphisms

Goran Papenberg et al.

JOURNAL OF COGNITIVE NEUROSCIENCE (2019)

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Article Medicine, General & Internal

Physical Activity versus Psychological Stress: Effects on Salivary Cortisol and Working Memory Performance

Pamela Ponce et al.

MEDICINA-LITHUANIA (2019)

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Article Behavioral Sciences

Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa

D. Iggena et al.

BEHAVIOURAL BRAIN RESEARCH (2019)

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Article Clinical Neurology

Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB

Sarah Mahboubi et al.

NATURE AND SCIENCE OF SLEEP (2019)

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Article Physiology

The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats

Zahra Jahangiri et al.

JOURNAL OF PHYSIOLOGICAL SCIENCES (2019)

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Article Clinical Neurology

Exercise increases caudate dopamine release and ventral striatal activation in Parkinson's disease

Matthew A. Sacheli et al.

MOVEMENT DISORDERS (2019)

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Article Rehabilitation

Treadmill exercise improves memory by up-regulating dopamine and down-regulating D2 dopamine receptor in traumatic brain injury rats

Il-Gyu Ko et al.

JOURNAL OF EXERCISE REHABILITATION (2019)

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Article Neurosciences

Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats

Damiana Leo et al.

JOURNAL OF NEUROSCIENCE (2018)

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Article Medicine, Research & Experimental

Long term treadmill exercise performed to chronic social isolated rats regulate anxiety behavior without improving learning

Ozge Selin Cevik et al.

LIFE SCIENCES (2018)

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Article Behavioral Sciences

Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment

Ali Ahmadalipour et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2018)

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Article Neurosciences

Exercise and low-level GABAA receptor inhibition modulate locomotor activity and the expression of BDNF accompanied by changes in epigenetic regulation in the hippocampus

Hiroshi Maejima et al.

NEUROSCIENCE LETTERS (2018)

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Article Multidisciplinary Sciences

Strength exercise weakens aerobic exercise-induced cognitive improvements in rats

Yongsheng Lan et al.

PLOS ONE (2018)

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Article Rehabilitation

Treadmill exercise and wheel exercise improve motor function by suppressing apoptotic neuronal cell death in brain inflammation rats

Sang-Hyuk Song et al.

JOURNAL OF EXERCISE REHABILITATION (2018)

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Article Neurosciences

Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms

Thais Cereser Vilela et al.

MOLECULAR NEUROBIOLOGY (2017)

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Article Medicine, Research & Experimental

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target

Jing Sun et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

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Article Neurosciences

Distinct Trajectories of Cortisol Response to Prolonged Acute Stress Are Linked to Affective Responses and Hippocampal Gray Matter Volume in Healthy Females

Roee Admon et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Neurosciences

VOLUNTARY EXERCISE INCREASES ADULT HIPPOCAMPAL NEUROGENESIS BY INCREASING GSK-3β ACTIVITY IN MICE

Jiankun Zang et al.

NEUROSCIENCE (2017)

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Article Neurosciences

DOPAMINE INDUCES GLUTAMATE ACCUMULATION IN ASTROCYTES TO DISRUPT NEURONAL FUNCTION LEADING TO PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY

Saidan Ding et al.

NEUROSCIENCE (2017)

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Article Biology

CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

Xiao-Wen Yu et al.

ELIFE (2017)

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Review Psychiatry

Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators

C. M. Hueston et al.

TRANSLATIONAL PSYCHIATRY (2017)

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Article Multidisciplinary Sciences

Running wheel training does not change neurogenesis levels or alter working memory tasks in adult rats

Cesar A. Acevedo-Triana et al.

PEERJ (2017)

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Review Medicine, General & Internal

The effects of chronic and acute physical activity on working memory performance in healthy participants: a systematic review with meta-analysis of randomized controlled trials

Azeem Rathore et al.

SYSTEMATIC REVIEWS (2017)

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Article Rehabilitation

Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats

Jun-Jang Jin et al.

JOURNAL OF EXERCISE REHABILITATION (2017)

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Article Neurosciences

Combining restricted diet with forced or voluntary exercises improves hippocampal BDNF and cognitive function in rats

Mahmoud A. Alomari et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2016)

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Article Neurosciences

Exercise Improves Cognitive Impairment and Dopamine Metabolism in MPTP-Treated Mice

Aderbal S. Aguiar et al.

NEUROTOXICITY RESEARCH (2016)

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Article Psychology, Biological

Acute stress and episodic memory retrieval: neurobiological mechanisms and behavioral consequences

Stephanie A. Gagnon et al.

YEAR IN COGNITIVE NEUROSCIENCE (2016)

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Article Clinical Neurology

Can physical exercise in old age improve memory and hippocampal function?

Emrah Duzel et al.

BRAIN (2016)

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Article Biochemistry & Molecular Biology

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

Krisztina Marosi et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Article Neurosciences

Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained

Miriam S. Nokia et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

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NATURE MEDICINE (2016)

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Review Behavioral Sciences

The effects of acute stress on core executive functions: A meta-analysis and comparison with cortisol

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NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

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Article Neurosciences

Voluntary exercise rescues sevoflurane-induced memory impairment in aged male mice

Dan Tian et al.

EXPERIMENTAL BRAIN RESEARCH (2016)

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Review Physiology

Redox Mechanism of Reactive Oxygen Species in Exercise

Feng He et al.

FRONTIERS IN PHYSIOLOGY (2016)

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Review Psychology

Physical Activity and Cognitive Vitality

Ruchika Shaurya Prakash et al.

ANNUAL REVIEW OF PSYCHOLOGY, VOL 66 (2015)

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Article Behavioral Sciences

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

Tugce Demirtas Sahin et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

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Article Behavioral Sciences

Assessing rodent hippocampal involvement in the novel object recognition task. A review

Sarah J. Cohen et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

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Article Biochemistry & Molecular Biology

The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects

M. Kondo et al.

MOLECULAR PSYCHIATRY (2015)

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Article Multidisciplinary Sciences

Physical Exercise Enhances Cognitive Flexibility as Well as Astrocytic and Synaptic Markers in the Medial Prefrontal Cortex

Adam T. Brockett et al.

PLOS ONE (2015)

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Article Pharmacology & Pharmacy

Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum

Kosuke Higashino et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

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Review Biochemistry & Molecular Biology

Ketogenic diets, mitochondria, and neurological diseases

Lindsey B. Gano et al.

JOURNAL OF LIPID RESEARCH (2014)

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Review Biotechnology & Applied Microbiology

Physical Exercise-Induced Adult Neurogenesis: A Good Strategy to Prevent Cognitive Decline in Neurodegenerative Diseases?

Suk-yu Yau et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Psychology, Developmental

Adolescent Neurodevelopment

Linda Patia Spear

JOURNAL OF ADOLESCENT HEALTH (2013)

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Review Neurosciences

DYNAMIC PLASTICITY: THE ROLE OF GLUCOCORTICOIDS, BRAIN-DERIVED NEUROTROPHIC FACTOR AND OTHER TROPHIC FACTORS

J. D. Gray et al.

NEUROSCIENCE (2013)

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Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running

Min Chul Lee et al.

NEUROSCIENCE LETTERS (2013)

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Review Pharmacology & Pharmacy

Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise

Thibault Renoir et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Article Developmental Biology

Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

Michael W. Marlatt et al.

DEVELOPMENTAL NEUROBIOLOGY (2012)

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Article Endocrinology & Metabolism

The Critical Role of Metabolic Pathways in Aging

Nir Barzilai et al.

DIABETES (2012)

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Article Clinical Neurology

Common factors among Alzheimer's disease, Parkinson's disease, and epilepsy: Possible role of the noradrenergic nervous system

Patricia Szot

EPILEPSIA (2012)

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Article Neurosciences

GABA(A) Receptor Blockade Enhances Memory Consolidation by Increasing Hippocampal BDNF Levels

Dong Hyun Kim et al.

NEUROPSYCHOPHARMACOLOGY (2012)

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Article Behavioral Sciences

The emerging role of norepinephrine in cognitive dysfunctions of Parkinson's disease

Elena M. Vazey et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2012)

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Article Endocrinology & Metabolism

Contribution of norepinephrine to emotional memory consolidation during sleep

Sabine Groch et al.

PSYCHONEUROENDOCRINOLOGY (2011)

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Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning

Jonathan L. Brigman et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Neurosciences

Longitudinal Evidence for Functional Specialization of the Neural Circuit Supporting Working Memory in the Human Brain

Amy S. Finn et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Neurosciences

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

Kirk I. Erickson et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Behavioral Sciences

BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

Michael E. Hopkins et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2010)

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Review Neurosciences

Emotional enhancement of memory: how norepinephrine enables synaptic plasticity

Keith Tully et al.

MOLECULAR BRAIN (2010)

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Article Neurosciences

Long-Term Treadmill Exposure Protects Against Age-Related Neurodegenerative Change in the Rat Hippocampus

Rachel M. O'Callaghan et al.

HIPPOCAMPUS (2009)

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Article Neurosciences

Exercise Enhances Hippocampal-Dependent Learning in the Rat: Evidence for a BDNF-Related Mechanism

Eadaoin W. Griffin et al.

HIPPOCAMPUS (2009)

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Article Biochemistry & Molecular Biology

Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats

Chang-Hun Chae et al.

NEUROCHEMISTRY INTERNATIONAL (2009)

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Article Neurosciences

VENLAFAXINE TREATMENT STIMULATES EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR PROTEIN IN FRONTAL CORTEX AND INHIBITS LONG-TERM POTENTIATION IN HIPPOCAMPUS

J. D. Cooke et al.

NEUROSCIENCE (2009)

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Article Neurosciences

Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats

Shu-jie Lou et al.

BRAIN RESEARCH (2008)

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Article Physiology

Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice

Chih-Wei Wu et al.

JOURNAL OF APPLIED PHYSIOLOGY (2008)

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Article Endocrinology & Metabolism

Exercise and circulating cortisol levels: The intensity threshold effect

E. E. Hill et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2008)

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Article Behavioral Sciences

Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system

Hsiun-Ing Chen et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2008)

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Article Neurosciences

Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats

M. Silhol et al.

NEUROSCIENCE (2007)

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Article Neurosciences

Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus

Cristina Vasuta et al.

HIPPOCAMPUS (2007)

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Running induces widespread structural alterations in the hippocampus and Entorhinal cortex

Alexis M. Stranahan et al.

HIPPOCAMPUS (2007)

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Article Mathematical & Computational Biology

Moderate exercise and chronic stress produce counteractive effects on different areas of the brain by acting through various neurotransmitter receptor subtypes: A hypothesis

Suptendra N. Sarbadhikari et al.

THEORETICAL BIOLOGY AND MEDICAL MODELLING (2006)

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Article Neurosciences

Exercise enhances learning and hippocampal neurogenesis in aged mice

H van Praag et al.

JOURNAL OF NEUROSCIENCE (2005)

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Review Behavioral Sciences

Action sets and decisions in the medial frontal cortex

MFS Rushworth et al.

TRENDS IN COGNITIVE SCIENCES (2004)

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VEGF links hippocampal activity with neurogenesis, learning and memory

L Cao et al.

NATURE GENETICS (2004)

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Article Behavioral Sciences

On the delay-dependent involvement of the hippocampus in object recognition memory

RS Hammond et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2004)

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Article Immunology

Interleukin-1β mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guerin in the rat hippocampus

K Palin et al.

BRAIN BEHAVIOR AND IMMUNITY (2004)

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Article Neurosciences

Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats

SB Lupien et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

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Review Neurosciences

Role of the serotonin 5-HT2A receptor in learning

JA Harvey

LEARNING & MEMORY (2003)

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Article Neurosciences

Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity

S Vaynman et al.

NEUROSCIENCE (2003)

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Article Neurosciences

Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray

R Molteni et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2002)

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Article Pharmacology & Pharmacy

Effects of physical training on functional activity of 5-HT1B receptors in rat central nervous system:: role of 5-HT-moduline

M Chennaoui et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2000)

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Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved

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