期刊
NEUROBIOLOGY OF AGING
卷 113, 期 -, 页码 7-14出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2022.01.007
关键词
Donkey; Neurodegeneration; Alzheimer's; Neurofibrillary tangles; Amyloid plaques
资金
- Fiona and Ian Russell Seed Corn Fund for Companion Animal Research
Neurodegenerative disorders are becoming increasingly important in ageing populations of animals and people. This study identified the characteristic lesions of Alzheimer's disease (AD) in the brains of donkeys, which may prompt further research on their metabolic status.
Neurodegenerative disorders are gaining ever more importance in ageing populations of animals and people. Altered insulin signaling and type II diabetes have been linked to the development of Alzheimer's disease (AD) in humans and AD-like neurodegeneration in other long-lived animals. Donkeys are unusual amongst domestic species for their exceptional longevity and are additionally predisposed to abnormalities of insulin metabolism similar to those found in humans. In this study, the parietal lobe and hippocampus of 13 aged ( > 30 years) and 2 younger control donkeys were evaluated immunohistologically for the presence, distribution, and frequency of neurofibrillary tangles (NFT) and amyloid plaques (AP); the characteristic lesions of AD. AP were in parietal cortices of 9 donkeys, with a predilection for deep sulci, and NFT-like structures were observed in 7 donkeys, primarily within cortical areas. No changes were observed in the control donkeys. This represents the first identification of both AP and NFT in equids and is a stimulus for future work assessing their metabolic status in parallel.(c) 2022 Elsevier Inc. All rights reserved.
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