期刊
NEURAL REGENERATION RESEARCH
卷 17, 期 1, 页码 203-+出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.314325
关键词
-
资金
- Midstream Research Program for Universities, Hong Kong Special Administrative Region, China [MRP-092-17X]
Lycium barbarum extract can inhibit the inflammatory response in microglial cells induced by oligomeric Aβ and promote anti-inflammatory response.
Lycium barbarum (LB) is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions, such as antioxidation, neuroprotection, and immune modulation. One of the main mechanisms of Alzheimer's disease is that microglia activated by amyloid beta (A beta) transform from the resting state to an M1 state and release pro-inflammatory cytokines to the surrounding environment. In the present study, immortalized microglial cells were pretreated with L. barbarum extract for 1 hour and then treated with oligomeric A beta for 23 hours. The results showed that LB extract significantly increased the survival of oligomeric A beta-induced microglial cells, downregulated the expression of M1 pro-inflammatory markers (inducible nitric oxide synthase, tumor necrosis factor alpha, interleukin-6, and interleukin-1 beta), and upregulated the expression of M2 anti-inflammatory markers (arginase-1, chitinase-like protein 3, and interleukin-4). LB extract also inhibited the oligomeric A beta-induced secretion of tumor necrosis factor alpha, interleukin-6, and interleukin-1 beta in microglial cells. The results of in vitro cytological experiments suggest that, in microglial cells, LB extract can inhibit oligomeric A beta-induced M1 polarization and concomitant inflammatory reactions, and promote M2 polarization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据