Neuroprotective agents effective against radiation damage of central nervous system

Ionizing radiation caused by medical treatments, nuclear events or even space flights can irreversibly damage structure and function of brain cells. That can result in serious brain damage, with memory and behavior disorders, or even fatal oncologic or neurodegenerative illnesses. Currently used treatments and drugs are mostly targeting biochemical processes of cell apoptosis, radiation toxicity, neuroinflammation, and conditions such as cognitive-behavioral disturbances or others that result from the radiation insult. With most drugs, the side effects and potential toxicity are also to be considered. Therefore, many agents have not been approved for clinical use yet. In this review, we focus on the latest and most effective agents that have been used in animal and also in the human research, and clinical treatments. They could have the potential therapeutical use in cases of radiation damage of central nervous system, and also in prevention considering their radioprotecting effect of nervous tissue.

Automated summary

Ionizing radiation can cause irreversible damage to brain cells, leading to serious brain damage and diseases. Current treatments target processes such as cell apoptosis and neuroinflammation. However, the potential side effects and toxicity of these treatments need to be considered. This review focuses on the latest and most effective agents for the treatment and prevention of radiation damage to the central nervous system.