期刊
NEURAL REGENERATION RESEARCH
卷 17, 期 8, 页码 1827-1832出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.332153
关键词
function reconstruction; motor neuron; nerve injury; nerve implant; Nissl staining; spinal cord; synaptophysin; targeted muscle reinnervation; tibial nerve; transection
资金
- National Natural Science Foundation of China [81760416, 81960419, 81927804]
- Science and Technology foundation of Guizhou Province [[2017]1226]
- Support Plan for High Level Talents in Guizhou High Education Institutions [KY[2018]056]
This study investigated the effect of TMR on injured motor neurons in rats. The results showed that TMR surgery can improve the reduction in hind limb motor function and atrophy caused by tibial nerve transection by enhancing nerve regeneration and increasing the number of myelin sheath and motor neurons.
Targeted muscle reinnervation (TMR) is a surgical procedure used to transfer residual peripheral nerves from amputated limbs to targeted muscles, which allows the target muscles to become sources of motor control information for function reconstruction. However, the effect of TMR on injured motor neurons is still unclear. In this study, we aimed to explore the effect of hind limb TMR surgery on injured motor neurons in the spinal cord of rats after tibial nerve transection. We found that the reduction in hind limb motor function and atrophy in mice caused by tibial nerve transection improved after TMR. TMR enhanced nerve regeneration by increasing the number of axons and myelin sheath thickness in the tibial nerve, increasing the number of anterior horn motor neurons, and increasing the number of choline acetyltransferase-positive cells and immunofluorescence intensity of synaptophysin in rat spinal cord. Our findings suggest that TMR may enable the reconnection of residual nerve fibers to target muscles, thus restoring hind limb motor function on the injured side.
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