Oligometastases: the art of providing metastases-directed therapy in prostate cancer

Article Oncology

Toxicity and Efficacy of Local Ablative, Image-guided Radiotherapy in Gallium-68 Prostate-specific Membrane Antigen Targeted Positron Emission Tomography-staged, Castration-sensitive Oligometastatic Prostate Cancer: The OLI-P Phase 2 Clinical Trial

Tobias Hoelscher et al.

Summary: This study suggests that local ablative radiotherapy (aRT) is safe and effective for patients with oligometastatic prostate cancer, and one in five patients had no recurrent prostate-specific antigen after 3 years. This may be an option to avoid systemic therapy in selected patients.

EUROPEAN UROLOGY ONCOLOGY (2022)

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Article Oncology

Metastasis-directed Therapy (SBRT) Guided by PET-CT 18F-CHOLINE Versus PET-CT 68Ga-PSMA in Castration-sensitive Oligorecurrent Prostate Cancer: A Comparative Analysis of Effectiveness

Rosario Mazzola et al.

Summary: New metabolic tracers have improved sensitivity and specificity for assessing tumor burden in prostate cancer. This study compared the impact of Gallium-68 prostate-specific membrane antigen (Ga-68-PSMA) and 18F-fluorocholine (F-18-choline) positron emission tomography (PET) in metastasis-directed therapy for castration-sensitive oligorecurrent prostate cancer patients. Ga-68-PSMA PET-guided therapy resulted in higher rates of androgen deprivation therapy-free survival compared to F-18-choline PET-guided treatments.

CLINICAL GENITOURINARY CANCER (2021)

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Review Oncology

Safety and Survival Rates Associated With Ablative Stereotactic Radiotherapy for Patients With Oligometastatic Cancer A Systematic Review and Meta-analysis

Eric J. Lehrer et al.

Summary: The meta-analysis shows that stereotactic ablative radiotherapy is relatively safe and clinically beneficial in patients with oligometastatic cancer, with low rates of toxic effects and acceptable survival rates. Further research is needed to validate these findings.

JAMA ONCOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic Value, Oncologic Outcomes, and Safety Profile of Image-Guided Surgery Technologies During Robot-Assisted Lymph Node Dissection with Sentinel Node Biopsy for Prostate Cancer

Elio Mazzone et al.

Summary: The study suggests that combining hybrid-SNB technique with robot-assisted radical prostatectomy can enhance the detection of nodal metastases and is associated with lower recurrence rates. The use of hybrid-SNB technique does not increase complication rates.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Medicine, General & Internal