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GUT (2009)
A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells
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Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
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Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
Ana Izcue et al.
IMMUNITY (2008)
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
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Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
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Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys
Jose C. Crispin et al.
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CTLA-4 control over Foxp3+ regulatory T cell function
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Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
Xuefang Cao et al.
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
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TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
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Sequential development of interleukin 2 dependent effector and regulatory T cells in response to endogenous systemic antigen
B Knoechel et al.
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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
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O Boyer et al.
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