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Illuminating the mechanism of monogenic antigen expression in trypanosomes

NATURE REVIEWS MICROBIOLOGY (2021)

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

Joana Faria et al.

Summary: The study reveals a mechanism in Trypanosoma brucei where a single expressed antigen-coding gene interacts with a major messenger RNA splicing locus in a specific nuclear compartment, ensuring monogenic expression. Specific proteins VEX1 and VEX2 are associated with an antigen exclusion complex, playing a role in this process of antigen transcription and mRNA splicing. Depletion of VEX2 results in loss of monogenic antigen expression and increased interactions between previously silent antigen genes and the splicing locus.

NATURE MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Antigenic variation in African trypanosomes

David Horn

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2014)

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Article Multidisciplinary Sciences

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei

Ali Kassem et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Multidisciplinary Sciences

A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei

M Navarro et al.

NATURE (2001)

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Illuminating the mechanism of monogenic antigen expression in trypanosomes

相关参考文献

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

Antigenic variation in African trypanosomes

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei

A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei

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