期刊
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
卷 30, 期 1, 页码 51-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2015.10.012
关键词
Antifungal; Spectrum of activity; Azole; Echinocandins; Amphotericin B; Pharmacokinetics; Indications; Toxicity
The currently available antifungal therapies vary significantly in terms of spectrum of activity, pharmacologic properties, toxicity, and potential for drug-drug interactions. This article provides a history of antifungal development and discusses the characteristics of individual drugs and drug classes, including the amphotericin B formulations, the triazoles, the echinocandins, and flucytosine. For each drug, the clinically relevant pharmacokinetics are reviewed, the spectrum of activity described, and the Food and Drug Administration-approved clinical indications examined. Anti fungal side-effects, therapeutic drug monitoring, and drug-drug interactions are summarized. The variations among different formulations are highlighted.
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