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Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
Brendan A. I. Payne et al.
NATURE GENETICS (2011)
T16189C mitochondrial DNA variant is associated with metabolic syndrome in Caucasian subjects
Vincenzo Ostilio Palmieri et al.
NUTRITION (2011)
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
Lisa S. Shock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
Mitochondrial dysfunction and lipotoxicity
Patrick Schrauwen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)
Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes
Agnieszka Biala et al.
BLOOD PRESSURE (2010)
Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
Kristel Brys et al.
BMC BIOLOGY (2010)
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Shinichi Someya et al.
CELL (2010)
AMP-activated protein kinase and its downstream transcriptional pathways
Carles Canto et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
E. Phielix et al.
DIABETOLOGIA (2010)
The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance
Ines Pagel-Langenickel et al.
ENDOCRINE REVIEWS (2010)
Overview of the immune response
David D. Chaplin
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)
Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1
Soeren Mai et al.
JOURNAL OF CELL SCIENCE (2010)
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
Shinji Kume et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
R. Scott Rector et al.
JOURNAL OF HEPATOLOGY (2010)
Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1α in Long-Lived Mclk1+/- Mouse Mutants
Dantong Wang et al.
JOURNAL OF IMMUNOLOGY (2010)
A Mitochondria-Targeted Vitamin E Derivative Decreases Hepatic Oxidative Stress and Inhibits Fat Deposition in Mice
Gaowei Mao et al.
JOURNAL OF NUTRITION (2010)
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Joao F. Passos et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
Jaime M. Ross et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Extending Healthy Life Span-From Yeast to Humans
Luigi Fontana et al.
SCIENCE (2010)
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
Eric Verdin et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
Orsolya M. Palacios et al.
AGING-US (2009)
Coronary Aging in HIV-Infected Patients
Giovanni Guaraldi et al.
CLINICAL INFECTIOUS DISEASES (2009)
Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes
M. J. MacDonald et al.
DIABETOLOGIA (2009)
Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations?
Raj S. Bhopal et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2009)
Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice
Reyhan Westbrook et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Nao Hosokawa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott et al.
NATURE (2009)
MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
Jan H. J. Hoeijmakers
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Mitochondrial DNA mutations and aging: devils in the details?
Konstantin Khrapko et al.
TRENDS IN GENETICS (2009)
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Camille C. Caldeira da Silva et al.
AGING CELL (2008)
Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities
Shane R. Thomas et al.
ANTIOXIDANTS & REDOX SIGNALING (2008)
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction
Philip Wenzel et al.
CARDIOVASCULAR RESEARCH (2008)
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Pazit Polak et al.
CELL METABOLISM (2008)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger et al.
CELL METABOLISM (2008)
Lower Intrinsic ADP-Stimulated: Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
Esther Phielix et al.
DIABETES (2008)
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
C. Ling et al.
DIABETOLOGIA (2008)
p66Shc-generated Oxidative Signal Promotes Fat Accumulation
Ina Berniakovich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression
Joao S. Teodoro et al.
MITOCHONDRION (2008)
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Bong-Hyun Ahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome
A. Kotronen et al.
DIABETOLOGIA (2008)
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice
Masa Katic et al.
AGING CELL (2007)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
Nidhi Ahuja et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
Xiaochun Bai et al.
SCIENCE (2007)
Somatic mtDNA mutations cause progressive hearing loss in the mouse
Xianzhi Niu et al.
EXPERIMENTAL CELL RESEARCH (2007)
HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty
Loic Desquilbet et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
Tim J. Schulz et al.
CELL METABOLISM (2007)
Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
Frederico G. S. Toledo et al.
DIABETES (2007)
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Sibylle Jaeger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases
Andrew M. James et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Joao F. Passos et al.
PLOS BIOLOGY (2007)
Mitochondrial point mutations do not limit the natural lifespan of mice
Marc Vermulst et al.
NATURE GENETICS (2007)
Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress
Giovanni G. Camici et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians
Noriyuki Fuku et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
Anthony E. Civitarese et al.
PLOS MEDICINE (2007)
Women with mitochondrial haplogroup N9a are protected against metabolic syndrome
Masashi Tanaka et al.
DIABETES (2007)
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
Richard M. Reznick et al.
CELL METABOLISM (2007)
Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function
Dolca A. Thomas et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
α-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein e-deficient mice fed high-fat/low-cholesterol diet
Xianwen Yi et al.
DIABETES (2006)
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene
Marcello Rota et al.
CIRCULATION RESEARCH (2006)
Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis
J Teodoro et al.
FEBS LETTERS (2006)
Pathogen recognition and innate immunity
S Akira et al.
CELL (2006)
Ageing and vascular ageing
B. Jani et al.
POSTGRADUATE MEDICAL JOURNAL (2006)
Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX
SG Kang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
E Nisoli et al.
SCIENCE (2005)
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
M Giorgio et al.
CELL (2005)
NASH: a mitochondrial disease
D Pessayre et al.
JOURNAL OF HEPATOLOGY (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells:: Relationship to oxidative stress
E Pagnin et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
M Anello et al.
DIABETOLOGIA (2005)
Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing
I Eskurza et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
A Brunet et al.
SCIENCE (2004)
Deletion of p66shc gene protects against age-related endothelial dysfunction
P Francia et al.
CIRCULATION (2004)
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A Trifunovic et al.
NATURE (2004)
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
ML Jauslin et al.
FASEB JOURNAL (2003)
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
VK Mootha et al.
NATURE GENETICS (2003)
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
KF Petersen et al.
SCIENCE (2003)
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
RM Anderson et al.
NATURE (2003)
Glucose toxicity in β-cells:: Type 2 diabetes, good radicals gone bad, and the glutathione connection
RP Robertson et al.
DIABETES (2003)
Extended longevity in mice lacking the insulin receptor in adipose tissue
M Blüher et al.
SCIENCE (2003)
RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress
K Kirby et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
HH Zong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The presence of a common mitochondrial DNA variant is associated with fasting insulin levels in Europeans in Auckland
J Poulton et al.
DIABETIC MEDICINE (2002)
In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance
S Kopprasch et al.
DIABETES (2002)
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
DE Kelley et al.
DIABETES (2002)
The prevalence of the mitochondrial DNA 16189 variant in non-diabetic Korean adults and its association with higher fasting glucose and body mass index
JH Kim et al.
DIABETIC MEDICINE (2002)
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
SJ Lin et al.
NATURE (2002)
Endogenous oxidative stress: relationship to aging, longevity and caloric restriction
G Barja
AGEING RESEARCH REVIEWS (2002)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
WC Knowler et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Andropause: Clinical implications of the decline in serum testosterone levels with aging in men
AM Matsumoto
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2002)
Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
S Melov et al.
JOURNAL OF NEUROSCIENCE (2001)
Uncoupling to survive? The role of mitochondrial inefficiency in ageing
MD Brand
EXPERIMENTAL GERONTOLOGY (2000)
Role of oxidants in NF-κB activation and TNF-α gene transcription induced by hypoxia and endotoxin
NS Chandel et al.
JOURNAL OF IMMUNOLOGY (2000)
Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue
M Rossmeisl et al.
FASEB JOURNAL (2000)