The emerging evidence for non-skeletal health benefits of vitamin D supplementation in adults

Article Cardiac & Cardiovascular Systems

Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk

Ang Zhou et al.

Summary: The study found a non-linear association between genetically predicted serum 25(OH)D concentration and CVD risk, with CVD risk initially decreasing steeply with increasing concentrations and leveling off at around 50 nmol/L. Correction of serum 25(OH)D level below 50 nmol/L was predicted to result in a 4.4% reduction in CVD incidence.

EUROPEAN HEART JOURNAL (2022)

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Review Endocrinology & Metabolism

The health effects of vitamin D supplementation: evidence from human studies

Roger Bouillon et al.

Summary: The review highlights that vitamin D supplementation in vitamin D-replete adults does not provide significant health benefits, but vitamin D deficiency should be corrected. The vitamin D supplementation can prevent and cure nutritional rickets in infants and children.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Article Endocrinology & Metabolism

The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality

Prakash Acharya et al.

Summary: In this study, treatment with vitamin D in patients with vitamin D deficiency and no prior history of myocardial infarction significantly reduced the risk of myocardial infarction and all-cause mortality. Maintaining vitamin D levels above 30 ng/mL was associated with a more significant reduction in the risk of myocardial infarction.

JOURNAL OF THE ENDOCRINE SOCIETY (2021)

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Article Endocrinology & Metabolism

The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality

Prakash Acharya et al.

Summary: For patients with Vitamin D deficiency and no prior history of myocardial infarction, treatment to reach 25-hydroxyvitamin D levels above 20 ng/mL and 30 ng/mL is associated with significantly lower risk of all-cause mortality. The lower risk of myocardial infarction is only observed in individuals maintaining 25-OH levels above or equal to 30 ng/mL.

JOURNAL OF THE ENDOCRINE SOCIETY (2021)

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Article Endocrinology & Metabolism