期刊
NATURE REVIEWS ENDOCRINOLOGY
卷 18, 期 5, 页码 261-262出版社
NATURE PORTFOLIO
DOI: 10.1038/s41574-022-00635-0
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Weight gain can be caused by either a positive energy balance leading to weight gain or weight gain resulting in a positive energy balance. This integrated model of obesity pathogenesis incorporates both pathways.
Weight gain indicates a positive energy balance, with calorie intake exceeding expenditure. However, this fact of physics cannot inform causality. Potential pathways to obesity include a positive energy balance that drives weight gain or weight gain that drives the positive energy balance. Here, we propose an integrated model of obesity pathogenesis that incorporates both pathways.
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