Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Letter Virology

Myocardial injury characterized by elevated cardiac troponin and in-hospital mortality of COVID-19: An insight from a meta-analysis

Tadao Aikawa et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Medicine, General & Internal

Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

Guy Witberg et al.

Summary: Among 2.5 million patients who received the BNT162b2 mRNA vaccine in a large Israeli health care system, the incidence of myocarditis at 42 days was 2.13 cases per 100,000 persons, with the highest incidence (10.69 per 100,000 persons) among male patients between the ages of 16 and 29 years. Most cases of myocarditis were mild or moderate.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel

D. Mevorach et al.

Summary: The incidence of myocarditis increased after receiving the BNT162b2 vaccine in Israel, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Nicola P. Klein et al.

Summary: This study conducted interim analysis of safety surveillance data of mRNA COVID-19 vaccines and found that the incidence of selected serious outcomes within 1-21 days post-vaccination was not significantly higher compared with 22-42 days post-vaccination. Surveillance is ongoing despite wide confidence intervals for many outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military

Jay Montgomery et al.

Summary: This study investigated cases of myocarditis occurring in male patients within the US Military Health System after receiving mRNA COVID-19 vaccines between January and April 2021. A total of 23 male patients presented with acute chest pain within 4 days post-vaccination, with elevated troponin levels and findings consistent with myocarditis on imaging. The number of cases observed was higher than expected after a second dose of the vaccine among male military members.

JAMA CARDIOLOGY (2021)

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Review Medicine, General & Internal

Myocardial Pathology in COVID-19-Associated Cardiac Injury: A Systematic Review

Aniello Maiese et al.

Summary: This systematic review analyzed the potential impacts of COVID-19 on the heart, revealing that SARS-CoV-2 can cause irreversible changes in the heart, increasing cardiac risks in surviving patients. Postmortem analysis is an essential tool to understand the pathological changes caused by COVID-19.

DIAGNOSTICS (2021)

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Letter Immunology

Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases

Aristo Vojdani et al.

CLINICAL IMMUNOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy

Stephane Heymans et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

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Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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