Non-fatal MI as surrogate end point for all-cause or cardiovascular mortality

In a pooled analysis of 144 high-quality randomized trials involving patients with coronary artery disease, application of the most stringent criteria for surrogacy demonstrated that a reduction in the rates of non-fatal myocardial infarction by any intervention did not necessarily predict a reduction in all-cause or cardiovascular mortality during follow-up.

Automated summary

In a study on patients with coronary artery disease, it was found that reducing the occurrence of non-fatal myocardial infarctions does not necessarily lead to a reduction in overall or cardiovascular mortality.