4.7 Article

Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Structural equilibrium underlying ligand-dependent activation of β2-adrenoreceptor

Shunsuke Imai et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands

Luyu Fan et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

Reid H. J. Olsen et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

Kuglae Kim et al.

Article Multidisciplinary Sciences

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane

Jie Yin et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

Dohyun Im et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine

Kanako Terakado Kimura et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

Carmen Klein Herenbrink et al.

ACS CHEMICAL BIOLOGY (2019)

Article Chemistry, Medicinal

Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

Marton Vass et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

John D. McCorvy et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Biochemical Research Methods

KAMO: towards automated data processing for microcrystals

Keitaro Yamashita et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)

Article Multidisciplinary Sciences

Binding kinetics of cariprazine and aripiprazole at the dopamine D-3 receptor

Annika Frank et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Dopamine D1 or D2 receptor-expressing neurons in the central nervous system

Xiaoyan Wei et al.

ADDICTION BIOLOGY (2018)

Review Clinical Neurology

Serotonin and brain function: a tale of two receptors

R. L. Carhart-Harris et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2017)

Review Behavioral Sciences

The influence of the glutamatergic system on cognition in schizophrenia: A systematic review

Elizabeth H. X. Thomas et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Chemistry, Medicinal

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists

Xin Chen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Wesley K. Kroeze et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Wesley K. Kroeze et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Clozapine, a Fast-Off-D2 Antipsychotic

Philip Seeman

ACS CHEMICAL NEUROSCIENCE (2014)

Article Chemistry, Medicinal

Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT6 and Dopamine D2 Receptor Ligands

Niels Krogsgaard-Larsen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Pharmacology & Pharmacy

Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

Kenji Maeda et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

Article Biochemical Research Methods

Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography

James Foadi et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

G. Madhavi Sastry et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)

Review Multidisciplinary Sciences

Molecular signatures of G-protein-coupled receptors

A. J. Venkatakrishnan et al.

NATURE (2013)

Article Chemistry, Medicinal

Structure-Functional Selectivity Relationship Studies of β-Arrestin-Biased Dopamine D2 Receptor Agonists

Xin Chen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Automated design of ligands to polypharmacological profiles

Jeremy Besnard et al.

NATURE (2012)

Review Pharmacology & Pharmacy

Serotonin 2A receptor antagonists for treatment of schizophrenia

Bjorn H. Ebdrup et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)

Article Clinical Neurology

Partial agonists in schizophrenia - why some work and others do not: insights from preclinical animal models

Sridhar Natesan et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2011)

Article Multidisciplinary Sciences

Discovery of β-Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

John A. Allen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemical Research Methods

Integration, scaling, space-group assignment and post-refinement

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Review Pharmacology & Pharmacy

Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

Joanna C. Neill et al.

PHARMACOLOGY & THERAPEUTICS (2010)

Article Biochemical Research Methods

Crystallizing membrane proteins using lipidic mesophases

Martin Caffrey et al.

NATURE PROTOCOLS (2009)

Article Pharmacology & Pharmacy

WAY-100635 has high selectivity for serotonin 5-HT1A versus dopamine D4 receptors

Jean-Claude Martel et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2007)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Article Psychiatry

Lifetime prevalence of psychotic and bipolar I disorders in a general population

Jonna Perala et al.

ARCHIVES OF GENERAL PSYCHIATRY (2007)

Article Chemistry, Medicinal

Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

Richard A. Friesner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Neurosciences

The neurocognitive effects of aripiprazole: an open-label comparison with olanzapine

Robert S. Kern et al.

PSYCHOPHARMACOLOGY (2006)

Article Chemistry, Medicinal

Novel procedure for modeling ligand/receptor induced fit effects

W Sherman et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

A hierarchical approach to all-atom protein loop prediction

MP Jacobson et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)

Article Biotechnology & Applied Microbiology

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

BL Roth et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Review Clinical Neurology

Dopamine partial agonists - A new class of antipsychotic

JA Lieberman

CNS DRUGS (2004)

Article Neurosciences

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology

DA Shapiro et al.

NEUROPSYCHOPHARMACOLOGY (2003)

Review Neurosciences

Is there a role for 5-HT1A agonists in the treatment of depression?

P Blier et al.

BIOLOGICAL PSYCHIATRY (2003)

Article Nursing

Aripiprazole: A third generation of Antipsychotics begins?

NL Keltner et al.

PERSPECTIVES IN PSYCHIATRIC CARE (2002)