期刊
NATURE MEDICINE
卷 28, 期 3, 页码 496-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-022-01715-4
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资金
- BioSysM liquid handling unit (LMU Munich)
- BMBF initiative NaFoUniMedCovid19 [01KX2021]
- Bavarian research alliance FOR-COVID
- Bavarian research networks Bay-VOC
- CoVaKo
- project 'virological and immunological determinants of COVID-19 pathogenesis - lessons to get prepared for future pandemics' [KA1-Co-02]
- Helmholtz Association's Initiative and Networking Fund
- CoVRapid consortium - Bavarian Research Foundation
This study reports on the dynamics of neutralizing antibodies in individuals convalescing from coronavirus disease 2019 or who are vaccine-naive and subsequently vaccinated. The findings suggest that infection-plus-vaccination-induced hybrid immunity or triple immunization can induce high-quality antibodies with superior neutralization capacity against variants of concern, including omicron.
Infection-neutralizing antibody responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an essential component of antiviral immunity. Antibody-mediated protection is challenged by the emergence of SARS-CoV-2 variants of concern (VoCs) with immune escape properties, such as omicron (B.1.1.529), which is rapidly spreading worldwide. Here we report neutralizing antibody dynamics in a longitudinal cohort of coronavirus disease 2019 convalescent and infection-naive individuals vaccinated with mRNA BNT162b2 by quantifying SARS-CoV-2 spike protein antibodies and determining their avidity and neutralization capacity in serum. Using live-virus neutralization assays, we show that a superior infection-neutralizing capacity against all VoCs, including omicron, developed after either two vaccinations in convalescents or a third vaccination or breakthrough infection of twice-vaccinated, naive individuals. These three consecutive spike antigen exposures resulted in an increasing neutralization capacity per anti-spike antibody unit and were paralleled by stepwise increases in antibody avidity. We conclude that an infection-plus-vaccination-induced hybrid immunity or a triple immunization can induce high-quality antibodies with superior neutralization capacity against VoCs, including omicron.
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