Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'

Editorial Material Immunology

Lack of evidence for intergenerational inheritance of immune resistance to infections

Eva Kaufmann et al.

NATURE IMMUNOLOGY (2022)

Article Immunology

Transient systemic inflammation in adult male mice results in underweight progeny

Sushama Rokade et al.

Summary: The study demonstrated that transient systemic inflammation leads to local inflammation in the testes, with persistent consequences for fetal development, including decreased sperm count and testosterone levels.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)

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Article Immunology

Transmission of trained immunity and heterologous resistance to infections across generations

Natalie Katzmarski et al.

Summary: Research demonstrates that trained immunity can be inherited by murine progeny, enhancing protection against infections. This inheritance is evidenced by cellular, developmental, transcriptional, and epigenetic changes, as well as DNA methylation differences in the sperm DNA of parent male mice infected with Candida albicans.

NATURE IMMUNOLOGY (2021)

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Article Immunology

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

Sarah Gee et al.

Summary: The immune system of neonates born to mothers with SARS-CoV-2 infection during pregnancy is affected, with increased percentages of certain immune cells and enhanced cytokine functionality. Vertical transmission of SARS-CoV-2 seems limited, as evidenced by nonspecific immune imprinting and lack of SARS-CoV-2-specific IgM in neonates despite maternal IgG transfer.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

Ai Ing Lim et al.

Summary: Research suggests that maternal restricted infection during pregnancy can have permanent and tissue-specific impacts on offspring immunity, with maternal interleukin-6 playing a key role in this process. This may indicate that maternal infection can affect fetal intestinal immune homeostasis, leading to altered inflammatory immune responses in offspring.

SCIENCE (2021)

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Article Medicine, General & Internal

Parental Bacillus Calmette-Guerin vaccine scars decrease infant mortality in the first six weeks of life: A retrospective cohort study

M. L. T. Berendsen et al.

Summary: Parental BCG scars, especially maternal scars, were associated with significantly reduced early-life mortality, highlighting the importance of further research on the impact of inherited non-specific immunity and parental priming on child survival.

ECLINICALMEDICINE (2021)

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Article Cell Biology