Building enzymes from scratch

Combining computational design with directed evolution has the potential to deliver enzymes with new functions, yet so far de novo catalysts have been limited to a handful of model transformations. Now, a primitive computationally designed enzyme has been remodelled into an efficient enantioselective catalyst for the Morita-Baylis-Hillman reaction.

Automated summary

A computationally designed enzyme has been remodelled into an efficient enantioselective catalyst for the Morita-Baylis-Hillman reaction.