期刊
NATURE CELL BIOLOGY
卷 23, 期 11, 页码 1129-1135出版社
NATURE PORTFOLIO
DOI: 10.1038/s41556-021-00787-7
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资金
- Wellcome Trust [108413/A/15/D]
- Office of the Director, National Institutes of Health of the National Institutes of Health [OT2OD026682]
- CZI (Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation)
- Schmidt Futures [74]
The article discusses the efforts to harmonize and integrate different sources of cell type annotations into a reference cell ontology, showcasing how this unified ontology can advance the understanding of cell types across scientific communities. Teichmann and colleagues present ongoing efforts from consortia of the Human Cell Atlas to harmonize and integrate data sources into a reference cell ontology and highlight the contributions of cell ontologies to discovery.
Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body while at the same time raising the need to formalize this new knowledge. Here, we discuss current efforts to harmonize and integrate different sources of annotations of cell types and states into a reference cell ontology. We illustrate with examples how a unified ontology can consolidate and advance our understanding of cell types across scientific communities and biological domains. In this Perspective, Teichmann and colleagues present ongoing efforts from consortia of the Human Cell Atlas to harmonize and integrate data sources into a reference cell ontology and the contributions of cell ontologies to discovery.
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