WAVE complex regulation by force

The WAVE regulatory complex is well known as an orchestrator of actin dynamics at the leading edge of migrating cells. A recent study shows how mechanical effects can regulate the WAVE complex and explains the importance of forces generated by actin filaments to control new actin generation at the leading edge.

Automated summary

The study demonstrates how mechanical effects can regulate the WAVE complex and the importance of forces generated by actin filaments to control new actin generation at the leading edge.